Protein profile

VK055_2946

bacterial regulatory, luxR family protein

Genome: KpATCC43816

Gene: AIK81532.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GHW3
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Amino acids 188
Annotations 2
Features 10
PDB binders 0
Druggability 0.983

Overview

Basic information about this protein and its source genome.

Accession
VK055_2946
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK81532.1
Status
annotated
Amino acids
188
Structure source
AlphaFold + ColabFold
GO
GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
71.17

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.983
Structure A0A0H3GHW3
Pocket Pocket 12
P2Rank 0.652
Structure A0A0H3GHW3
Pocket Pocket 1
ColabFold model
FPocket 0.967 · Pocket 2
P2Rank 0.861 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 16 / 4744 genomes with a hit
Normalized 0.003

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

Sequence Features

Domain/signature hits from InterPro and related databases.

10 records
Show feature table
Start End DB Term Name
121 171 Pfam PF00196 Bacterial regulatory proteins, luxR family
121 171 InterPro IPR000792 Transcription regulator LuxR, C-terminal
114 179 ProSiteProfiles PS50043 LuxR-type HTH domain profile.
114 179 InterPro IPR000792 Transcription regulator LuxR, C-terminal
90 184 Gene3D G3DSA:1.10.10.10 -
90 184 InterPro IPR036388 Winged helix-like DNA-binding domain superfamily
115 182 SUPERFAMILY SSF46894 C-terminal effector domain of the bipartite response regulators
115 182 InterPro IPR016032 Signal transduction response regulator, C-terminal effector
118 175 SMART SM00421 luxrmega5
118 175 InterPro IPR000792 Transcription regulator LuxR, C-terminal

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GHW3
AlphaFold — — full sequence — Viewing
ColabFold VK055_2946
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
12 0.983

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 16.76 0.786
2 5.33 0.251
3 0.85 0.003