Protein profile

VK055_2951

poly-beta-1,6-N-acetyl-D-glucosamine biosynthesis protein PgaD

Genome: KpATCC43816

Gene: AIK81536.1 pgaD Structure source: AlphaFold + ColabFold UniProt A0A0H3GQE1
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Amino acids 149
Annotations 1
Features 11
PDB binders 0
Druggability 0.925

Overview

Basic information about this protein and its source genome.

Accession
VK055_2951
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK81536.1 pgaD
Status
annotated
Amino acids
149
Structure source
AlphaFold + ColabFold
GO
GO:0043709 The attachment of a cell to a solid substrate, via cell adhesion molecules, during the formation of a biofilm composed of microorganisms of the same species.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
63.38

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.925
Structure A0A0H3GQE1
Pocket Pocket 1
P2Rank
Structure A0A0H3GQE1
Pocket No pockets
ColabFold model
FPocket 0.677 · Pocket 4
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 22 / 4744 genomes with a hit
Normalized 0.005

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0043709 The attachment of a cell to a solid substrate, via cell adhesion molecules, during the formation of a biofilm composed of microorganisms of the same species.

Sequence Features

Domain/signature hits from InterPro and related databases.

11 records
Show feature table
Start End DB Term Name
20 40 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
41 59 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 19 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
58 80 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
6 132 Pfam PF13994 PgaD-like protein
6 132 InterPro IPR023829 Poly-beta-1,6-N-acetyl-D-glucosamine biosynthesis protein PgaD
6 134 NCBIfam TIGR03940 poly-beta-1,6-N-acetyl-D-glucosamine biosynthesis protein PgaD
6 134 InterPro IPR023829 Poly-beta-1,6-N-acetyl-D-glucosamine biosynthesis protein PgaD
21 43 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
60 80 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
81 149 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GQE1
AlphaFold — — full sequence — Viewing
ColabFold VK055_2951
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.925
9 0.477
12 0.444