Protein profile

VK055_3010

binding-protein-dependent transport system innermembrane component family protein

Genome: KpATCC43816

Gene: AIK81595.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GLZ7
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Amino acids 285
Annotations 2
Features 30
PDB binders 0
Druggability 0.658

Overview

Basic information about this protein and its source genome.

Accession
VK055_3010
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK81595.1
Status
annotated
Amino acids
285
Structure source
AlphaFold + ColabFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
47.541
Localization
CytoplasmicMembrane
ColabFold pLDDT
87.88

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.658
Structure A0A0H3GLZ7
Pocket Pocket 16
P2Rank 0.036
Structure A0A0H3GLZ7
Pocket Pocket 1
ColabFold model
FPocket 0.368 · Pocket 17
P2Rank 0.156 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 10 / 4744 genomes with a hit
Normalized 0.002

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

Sequence Features

Domain/signature hits from InterPro and related databases.

30 records
Show feature table
Start End DB Term Name
163 182 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
14 273 Gene3D G3DSA:1.10.3720.10 -
14 273 InterPro IPR035906 MetI-like superfamily
117 139 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
250 271 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
29 51 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
83 265 CDD cd06261 TM_PBP2
83 265 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
83 106 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
154 176 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
144 162 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
52 82 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
250 272 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 24 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
22 281 SUPERFAMILY SSF161098 MetI-like
22 281 InterPro IPR035906 MetI-like superfamily
25 51 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
21 276 PANTHER PTHR43357 INNER MEMBRANE ABC TRANSPORTER PERMEASE PROTEIN YDCV
107 117 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
118 143 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
196 218 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
218 249 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
194 217 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
102 279 Pfam PF00528 Binding-protein-dependent transport system inner membrane component
102 279 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
272 285 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
83 271 ProSiteProfiles PS50928 ABC transporter integral membrane type-1 domain profile.
83 271 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
183 193 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
83 105 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GLZ7
AlphaFold — — full sequence — Viewing
ColabFold VK055_3010
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
16 0.658
18 0.12
10 0.086
1 0.0

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 2.0 0.036
2 1.76 0.027
3 1.67 0.023
4 1.39 0.014
5 0.93 0.004