Protein profile

VK055_3066

sorbitol operon regulator

Genome: KpATCC43816

Gene: AIK81651.1 sorC Structure source: Experimental + ColabFold UniProt P37078
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Amino acids 315
Annotations 4
Features 13
PDB binders 0
Druggability 0.835

Overview

Basic information about this protein and its source genome.

Accession
VK055_3066
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK81651.1 sorC
Status
annotated
Amino acids
315
Structure source
Experimental + ColabFold
GO
GO:0030246 Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006352 The initial step of transcription, consisting of the assembly of the RNA polymerase preinitiation complex (PIC) at a gene promoter, as well as the formation of the first few bonds of the RNA transcript. Transcription initiation includes abortive initiation events, which occur when the first few nucleotides are repeatedly synthesized and then released, and ends when promoter clearance takes place.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
86.984
DEG E-value
0.0
Localization
Cytoplasmic
ColabFold pLDDT
94.37

Selected Druggability evidence

PDB experimental structure

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.835
Structure 2W48
Pocket Pocket 1
P2Rank 0.812
Structure 2W48
Pocket Pocket 1
ColabFold model
FPocket 0.368 · Pocket 15
P2Rank 0.875 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 31 / 4744 genomes with a hit
Normalized 0.007

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0030246 Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates.
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
  • GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
  • GO:0006352 The initial step of transcription, consisting of the assembly of the RNA polymerase preinitiation complex (PIC) at a gene promoter, as well as the formation of the first few bonds of the RNA transcript. Transcription initiation includes abortive initiation events, which occur when the first few nucleotides are repeatedly synthesized and then released, and ends when promoter clearance takes place.

Sequence Features

Domain/signature hits from InterPro and related databases.

13 records
Show feature table
Start End DB Term Name
1 52 Gene3D G3DSA:1.10.10.60 -
7 315 PANTHER PTHR34294 TRANSCRIPTIONAL REGULATOR-RELATED
7 53 SUPERFAMILY SSF46689 Homeodomain-like
7 53 InterPro IPR009057 Homeobox-like domain superfamily
53 314 Gene3D G3DSA:3.40.50.1360 -
58 315 Pfam PF04198 Putative sugar-binding domain
58 315 InterPro IPR007324 Sugar-binding domain, putative
4 52 CDD cd00090 HTH_ARSR
4 52 InterPro IPR011991 ArsR-like helix-turn-helix domain
12 45 Pfam PF13936 Helix-turn-helix domain
12 45 InterPro IPR025246 Transposase IS30-like HTH domain
62 315 SUPERFAMILY SSF100950 NagB/RpiA/CoA transferase-like
62 315 InterPro IPR037171 NagB/RpiA transferase-like

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

1 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 2W48
X-ray 3.20 Å A,B,C,D
100.0% 1-315
PDBe RCSB PDBj File
Viewing
ColabFold VK055_3066
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
26 0.915
7 0.835
66 0.401
76 0.238

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 22.04 0.876
2 17.97 0.812
3 17.43 0.802
4 14.01 0.708
5 10.09 0.543