Protein profile

VK055_3074

sodium-dependent inorganic phosphate (Pi) transporter family protein

Genome: KpATCC43816

Gene: AIK81659.1 pnaS Structure source: AlphaFold + ColabFold UniProt A0A0H3GLT6

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Amino acids 518

Annotations 3

Features 40

PDB binders 0

Druggability 0.98

Overview

Basic information about this protein and its source genome.

Accession: VK055_3074
Assembly: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene: AIK81659.1 pnaS
Status: annotated
Amino acids: 518
Structure source: AlphaFold + ColabFold

GO:0044341 The directed movement of phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore, by a mechanism dependent upon sodium ions. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005436 Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + phosphate(out) = Na+(in) + phosphate(in).

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Human identity (%): 0.0
Gut microbiome off-target: hit
Essential (DEG): N
DEG identity (%): 0.0
Localization: CytoplasmicMembrane
ColabFold pLDDT: 86.87

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.98

Structure A0A0H3GLT6

Pocket Pocket 1

P2Rank 0.605

Structure A0A0H3GLT6

Pocket Pocket 1

ColabFold model

FPocket 0.836 · Pocket 36

P2Rank 0.092 · Pocket 1

Core conservation Conserved core gene

Roary core

CoreCruncher core

Gut microbiome 112 / 4744 genomes with a hit

Normalized 0.024

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

GO:0044341 The directed movement of phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore, by a mechanism dependent upon sodium ions.
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
GO:0005436 Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + phosphate(out) = Na+(in) + phosphate(in).

Sequence Features

Domain/signature hits from InterPro and related databases.

40 records

Show feature table

Start	End	DB	Term	Name
1	20	Phobius	SIGNAL_PEPTIDE_N_REGION	N-terminal region of a signal peptide.
39	53	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
97	107	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
2	122	Pfam	PF02690	Na+/Pi-cotransporter
2	122	InterPro	IPR003841	Sodium-dependent phosphate transport protein
134	219	Pfam	PF02690	Na+/Pi-cotransporter
134	219	InterPro	IPR003841	Sodium-dependent phosphate transport protein
305	508	Gene3D	G3DSA:1.20.58.220	Phosphate transport system protein phou homolog 2; domain 2
305	508	InterPro	IPR038078	PhoU-like domain superfamily
130	149	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
1	283	NCBIfam	TIGR00704	Na/Pi-cotransporter II-related protein
1	283	InterPro	IPR004633	Na/Pi-cotransporter II-related/YqeW-like protein
150	173	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
108	129	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
42	495	NCBIfam	TIGR01013	sodium-dependent inorganic phosphate transporter
42	495	InterPro	IPR003841	Sodium-dependent phosphate transport protein
213	237	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
42	64	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
21	33	Phobius	SIGNAL_PEPTIDE_H_REGION	Hydrophobic region of a signal peptide.
74	96	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
179	201	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
4	275	NCBIfam	NF037997	Na/Pi symporter
3	77	PANTHER	PTHR10010	SOLUTE CARRIER FAMILY 34 SODIUM PHOSPHATE , MEMBER 2-RELATED
3	77	InterPro	IPR003841	Sodium-dependent phosphate transport protein
108	130	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
249	271	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
177	199	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
202	212	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
249	269	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
150	172	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
270	518	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
174	178	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
34	38	Phobius	SIGNAL_PEPTIDE_C_REGION	C-terminal region of a signal peptide.
54	72	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
1	38	Phobius	SIGNAL_PEPTIDE	Signal peptide region
73	78	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
295	506	SUPERFAMILY	SSF109755	PhoU-like
214	236	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
79	96	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
238	248	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold AF_A0A0H3GLT6	AlphaFold	—	—	full sequence	—	Viewing
ColabFold VK055_3074	ColabFold	—	—	full sequence	—	Loaded

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.98
20				0.818
7				0.202

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK	Score	Probability
1	13.15	0.676
2	2.02	0.044
3	1.7	0.03
4	1.53	0.023
5	1.47	0.02

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
36				0.836
8				0.751
33				0.232

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK	Score	Probability
1	5.43	0.258
2	1.86	0.037
3	1.7	0.03
4	1.5	0.021
5	1.27	0.013