Protein profile

VK055_3141

transcriptional activator RfaH

Genome: KpATCC43816

Gene: AIK81712.1 rfaH Structure source: ColabFold
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Amino acids 133
Annotations 2
Features 12
PDB binders 0
Druggability 0.819

Overview

Basic information about this protein and its source genome.

Accession
VK055_3141
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK81712.1 rfaH
Status
annotated
Amino acids
133
Structure source
ColabFold
GO
GO:0140673 A chromatin remodeling process that reestablishes the chromatin structure following the passage of RNA polymerase II during transcription elongation, thus preventing cryptic transcription initiation. GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
82.576
DEG E-value
2.52e-79
Localization
Unknown
ColabFold pLDDT
78.11

Selected Druggability evidence

ColabFold / curated model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.819
Structure CB_VK055_3141
Pocket Pocket 10
P2Rank
Structure CB_VK055_3141
Pocket No pockets
ColabFold model
FPocket 0.819 · Pocket 10
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 110 / 4744 genomes with a hit
Normalized 0.023

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0140673 A chromatin remodeling process that reestablishes the chromatin structure following the passage of RNA polymerase II during transcription elongation, thus preventing cryptic transcription initiation.
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

Sequence Features

Domain/signature hits from InterPro and related databases.

12 records
Show feature table
Start End DB Term Name
1 130 NCBIfam TIGR01955 transcription/translation regulatory transformer protein RfaH
1 130 InterPro IPR010215 Transcription antitermination protein RfaH
1 133 Gene3D G3DSA:3.30.70.940 -
1 133 InterPro IPR036735 NusG, N-terminal domain superfamily
2 132 PANTHER PTHR30265 RHO-INTERACTING TRANSCRIPTION TERMINATION FACTOR NUSG
2 132 InterPro IPR043425 NusG-like
1 69 SUPERFAMILY SSF82679 N-utilization substance G protein NusG, N-terminal domain
1 69 InterPro IPR036735 NusG, N-terminal domain superfamily
1 71 SMART SM00738 nusgn_4
1 71 InterPro IPR006645 NusG-like, N-terminal
2 66 Pfam PF02357 Transcription termination factor nusG
2 66 InterPro IPR006645 NusG-like, N-terminal

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
ColabFold VK055_3141
ColabFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
10 0.819