Protein profile

VK055_3150

putative dienelactone hydrolase

Genome: KpATCC43816

Gene: AIK81722.1 Structure source: Experimental + ColabFold UniProt A6TGL0
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Amino acids 270
Annotations 1
Features 7
PDB binders 0
Druggability 0.856

Overview

Basic information about this protein and its source genome.

Accession
VK055_3150
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK81722.1
Status
annotated
Amino acids
270
Structure source
Experimental + ColabFold
GO
GO:0016787 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
25.405
Human E-value
3.38e-08
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
95.33

Selected Druggability evidence

PDB experimental structure

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.856
Structure 3F67
Pocket Pocket 13
P2Rank 0.876
Structure 3F67
Pocket Pocket 1
ColabFold model
FPocket 0.534 · Pocket 10
P2Rank 0.855 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 98 / 4744 genomes with a hit
Normalized 0.021

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0016787 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.

Sequence Features

Domain/signature hits from InterPro and related databases.

7 records
Show feature table
Start End DB Term Name
42 265 Pfam PF01738 Dienelactone hydrolase family
42 265 InterPro IPR002925 Dienelactone hydrolase
33 264 SUPERFAMILY SSF53474 alpha/beta-Hydrolases
33 264 InterPro IPR029058 Alpha/Beta hydrolase fold
30 265 PANTHER PTHR46623 CARBOXYMETHYLENEBUTENOLIDASE-RELATED
26 265 Gene3D G3DSA:3.40.50.1820 alpha/beta hydrolase
26 265 InterPro IPR029058 Alpha/Beta hydrolase fold

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

1 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 3F67
X-ray 20.00 Å - —
PDBe RCSB PDBj File
Viewing
ColabFold VK055_3150
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
13 0.856

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 21.96 0.876