Metabolic network

VK055_3151

5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase

Back to protein
Network centrality 0.01019 top 90.5%
Chokepoint Yes

Attractive metabolic target: catalyzes a consuming chokepoint reaction in Cysteine and methionine metabolism, no isoenzyme backup detected, more central than 90.5% of genes in this genome, no human homolog detected.

Pathways

KEGG pathways this gene's reaction(s) belong to.

Cysteine and methionine metabolism Selenocompound metabolism

Network

Two-hop reaction neighborhood around this protein; pathway boxes use one primary KEGG route per reaction when several mappings exist. Click a pathway box to open its full route map.

Reaction catalyzed by this protein Chokepoint reaction Neighbor reaction Pathway grouping (2+ reactions sharing a route) Connected reaction (arrow shows direction, when known) ⇌ Reversible reaction (double arrow) Cross-pathway connection

Selected reaction

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Isoenzymes
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Catalyzed reactions

Every reaction this gene catalyzes, with substrates/products and isoenzyme backup.

HOMOCYSMET-RXN

EC 2.1.1.14 · HOMOCYSMET-RXN · not reversible · 3 isoenzymes

5-methyltetrahydropteroyl tri-L-glutamate L-homocysteine
→
tetrahydropteroyl tri-L-glutamate L-methionine

RXN-12730

EC 2.1.1.14 · RXN-12730 · not reversible · no isoenzyme backup

Consuming chokepoint
seleno-L-homocysteine 5-methyltetrahydropteroyl tri-L-glutamate
→
L-selenomethionine tetrahydropteroyl tri-L-glutamate

Imported from KpATCC43816.sbml · 2026-07-09