Protein profile

VK055_3212

hdfR transcriptional regulator HdfR transcriptional repressor

Genome: KpATCC43816

Gene: hdfR AIK81780.1 Structure source: ColabFold
Export view
Amino acids 229
Annotations 0
Features 7
PDB binders 0
Druggability 0.66

Overview

Basic information about this protein and its source genome.

Accession
VK055_3212
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
hdfR AIK81780.1
Status
annotated
Amino acids
229
Structure source
ColabFold

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
77.586
DEG E-value
1.71e-132
Localization
Unknown
ColabFold pLDDT
91.12

Selected Druggability evidence

ColabFold / curated model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.66
Structure CB_VK055_3212
Pocket Pocket 1
P2Rank 0.15
Structure CB_VK055_3212
Pocket Pocket 1
ColabFold model
FPocket 0.66 · Pocket 1
P2Rank 0.15 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 89 / 4744 genomes with a hit
Normalized 0.019

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

7 records
Show feature table
Start End DB Term Name
43 220 Pfam PF03466 LysR substrate binding domain
43 220 InterPro IPR005119 LysR, substrate-binding
1 43 Gene3D G3DSA:1.10.10.10 -
1 43 InterPro IPR036388 Winged helix-like DNA-binding domain superfamily
44 137 Gene3D G3DSA:3.40.190.10 -
2 224 PANTHER PTHR30579 TRANSCRIPTIONAL REGULATOR
45 216 SUPERFAMILY SSF53850 Periplasmic binding protein-like II

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
ColabFold VK055_3212
ColabFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.66
16 0.112
11 0.064
13 0.062

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 4.35 0.15
2 3.34 0.094
3 1.8 0.028
4 0.68 0.001