Metabolic network

VK055_3237

5,10-methylenetetrahydrofolate reductase

Back to protein
Network centrality 0.09556 top 97.3%
Chokepoint No

Metabolic context: more central than 97.3% of genes in this genome.

Pathways

KEGG pathways this gene's reaction(s) belong to.

One carbon pool by folate Other carbon fixation pathways

Network

Two-hop reaction neighborhood around this protein; pathway boxes use one primary KEGG route per reaction when several mappings exist. Click a pathway box to open its full route map.

Reaction catalyzed by this protein Chokepoint reaction Neighbor reaction Pathway grouping (2+ reactions sharing a route) Connected reaction (arrow shows direction, when known) ⇌ Reversible reaction (double arrow) Cross-pathway connection

Selected reaction

Click a node in the network above, or a row in the table below, to inspect it here.

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Isoenzymes
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Catalyzed reactions

Every reaction this gene catalyzes, with substrates/products and isoenzyme backup.

RXN-22438

EC 1.5.1.54 · RXN-22438 · reversible · no isoenzyme backup

a 5-methyltetrahydrofolate NAD+
⇌
a 5,10-methylenetetrahydrofolate NADH H+

1.5.1.20-RXN

EC 1.5.1.20 · 1.5.1.20-RXN · reversible · no isoenzyme backup

a 5-methyltetrahydrofolate NAD(P)+
⇌
a 5,10-methylenetetrahydrofolate NAD(P)H H+

Imported from KpATCC43816.sbml · 2026-07-09