Protein profile

VK055_3245

ribosomal protein L31

Genome: KpATCC43816

Gene: AIK81806.1 rpmE2 Structure source: AlphaFold + ColabFold UniProt A0A0H3GLG0
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Amino acids 49
Annotations 4
Features 15
PDB binders 0
Druggability 0.172

Overview

Basic information about this protein and its source genome.

Accession
VK055_3245
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK81806.1 rpmE2
Status
annotated
Amino acids
49
Structure source
AlphaFold + ColabFold
GO
GO:0003735 The action of a molecule that contributes to the structural integrity of the ribosome. GO:0006412 The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome. GO:0005840 An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. GO:1990904 A macromolecular complex that contains both RNA and protein molecules.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
95.918
DEG E-value
1.32e-30
Localization
Cytoplasmic
ColabFold pLDDT
61.49

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.172
Structure A0A0H3GLG0
Pocket Pocket 1
P2Rank
Structure A0A0H3GLG0
Pocket No pockets
ColabFold model
FPocket 0.254 · Pocket 2
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 1374 / 4744 genomes with a hit
Normalized 0.29

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0003735 The action of a molecule that contributes to the structural integrity of the ribosome.
  • GO:0006412 The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome.
  • GO:0005840 An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins.
  • GO:1990904 A macromolecular complex that contains both RNA and protein molecules.

Sequence Features

Domain/signature hits from InterPro and related databases.

15 records
Show feature table
Start End DB Term Name
3 45 SUPERFAMILY SSF143800 L28p-like
3 45 InterPro IPR034704 L28p-like
2 43 Pfam PF01197 Ribosomal protein L31
2 43 InterPro IPR002150 Ribosomal protein L31
10 25 PRINTS PR01249 Ribosomal protein L31 signature
10 25 InterPro IPR002150 Ribosomal protein L31
25 43 PRINTS PR01249 Ribosomal protein L31 signature
25 43 InterPro IPR002150 Ribosomal protein L31
14 35 ProSitePatterns PS01143 Ribosomal protein L31 signature.
14 35 InterPro IPR002150 Ribosomal protein L31
1 49 Gene3D G3DSA:4.10.830.30 Ribosomal protein L31
1 49 InterPro IPR042105 Ribosomal protein L31 superfamily
1 44 PANTHER PTHR33280 50S RIBOSOMAL PROTEIN L31, CHLOROPLASTIC
1 44 InterPro IPR002150 Ribosomal protein L31
1 44 NCBIfam TIGR00105 50S ribosomal protein L31

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GLG0
AlphaFold — — full sequence — Viewing
ColabFold VK055_3245
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer