Protein profile

VK055_3307

molybdopterin-guanine dinucleotide biosynthesis protein B

Genome: KpATCC43816

Gene: AIK81868.1 mobB Structure source: AlphaFold + ColabFold UniProt A0A0H3GGT3
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Amino acids 168
Annotations 2
Features 16
PDB binders 0
Druggability 0.437

Overview

Basic information about this protein and its source genome.

Accession
VK055_3307
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK81868.1 mobB
Status
annotated
Amino acids
168
Structure source
AlphaFold + ColabFold
GO
GO:0005525 Binding to GTP, guanosine triphosphate. GO:0006777 The chemical reactions and pathways resulting in the formation of the Mo-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear molybdenum (Mo) ion coordinated by one or two molybdopterin ligands.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
53.049
DEG E-value
2.26e-56
Localization
Cytoplasmic
ColabFold pLDDT
94.08

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.437
Structure A0A0H3GGT3
Pocket Pocket 2
P2Rank 0.043
Structure A0A0H3GGT3
Pocket Pocket 1
ColabFold model
FPocket 0.475 · Pocket 1
P2Rank 0.028 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 139 / 4744 genomes with a hit
Normalized 0.029

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0005525 Binding to GTP, guanosine triphosphate.
  • GO:0006777 The chemical reactions and pathways resulting in the formation of the Mo-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear molybdenum (Mo) ion coordinated by one or two molybdopterin ligands.

Sequence Features

Domain/signature hits from InterPro and related databases.

16 records
Show feature table
Start End DB Term Name
1 14 Phobius SIGNAL_PEPTIDE Signal peptide region
15 168 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
10 14 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
3 167 PANTHER PTHR40072 MOLYBDOPTERIN-GUANINE DINUCLEOTIDE BIOSYNTHESIS ADAPTER PROTEIN-RELATED
1 1 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
5 139 Pfam PF03205 Molybdopterin guanine dinucleotide synthesis protein B
5 139 InterPro IPR004435 Molybdopterin-guanine dinucleotide biosynthesis protein B (MobB) domain
2 168 Gene3D G3DSA:3.40.50.300 -
2 168 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
3 161 CDD cd03116 MobB
1 168 FunFam G3DSA:3.40.50.300:FF:000920 Molybdopterin-guanine dinucleotide biosynthesis protein B
5 164 NCBIfam TIGR00176 molybdopterin-guanine dinucleotide biosynthesis protein B
5 164 InterPro IPR004435 Molybdopterin-guanine dinucleotide biosynthesis protein B (MobB) domain
2 166 SUPERFAMILY SSF52540 P-loop containing nucleoside triphosphate hydrolases
2 166 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
2 9 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GGT3
AlphaFold — — full sequence — Viewing
ColabFold VK055_3307
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
14 0.112
8 0.012
7 0.0
12 0.0

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 2.17 0.043
2 1.65 0.023