KEGG:map00790

Folate biosynthesis

KpATCC43816 - Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

All pathways Protein ranking
Reactions 15
Proteins 12
Metabolites 41
Chokepoints 9

Pathway map

Reaction-to-metabolite flow reconstructed from the imported SBML participants.

Chokepoint reaction Metabolite ⇌ Reversible reaction Currency metabolites hidden
Computing layout…

Connected pathways

Other pathways in this genome that share reactions with this one.

MODEL Unassigned metabolic reactions 19 shared KEGG Purine metabolism 2 shared KEGG Glyoxylate and dicarboxylate metabolism 1 shared KEGG Phenylalanine, tyrosine and tryptophan biosynthesis 1 shared

Reaction table

Catalyzed reactions, mapped genes, and SBML substrates/products.

ADCLY-RXN

EC 4.1.3.38 · R05553 · ADCLY-RXN · not reversible

consuming
4-amino-4-deoxychorismate
→
4-aminobenzoate pyruvate H+
VK055_1371

DIHYDROFOLATESYNTH-RXN

EC 6.3.2.12 · R02237 · DIHYDROFOLATESYNTH-RXN · not reversible

consuming
7,8-dihydropteroate L-glutamate ATP
→
7,8-dihydrofolate monoglutamate ADP H+ phosphate
VK055_4808

DIHYDRONEOPTERIN-MONO-P-DEPHOS-RXN

EC 3.6.1.- · R04621 · DIHYDRONEOPTERIN-MONO-P-DEPHOS-RXN · not reversible

7,8-dihydroneopterin 3'-phosphate H2O
→
D-erythro-7,8-dihydroneopterin phosphate
No mapped protein

GTP-CYCLOHYDRO-II-RXN

EC 3.5.4.25 · R00425 · GTP-CYCLOHYDRO-II-RXN · not reversible

producing
GTP H2O
→
2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one formate H+ phosphate
VK055_1178

H2NEOPTERINALDOL-RXN

EC 4.1.2.25 · R03504 · H2NEOPTERINALDOL-RXN · not reversible

consuming
D-erythro-7,8-dihydroneopterin
→
6-(hydroxymethyl)-7,8-dihydropterin glycolaldehyde
VK055_4010

H2NEOPTERINP3PYROPHOSPHOHYDRO-RXN

EC 3.6.1.67 · R04638 · H2NEOPTERINP3PYROPHOSPHOHYDRO-RXN · not reversible

7,8-dihydroneopterin 3'-triphosphate H2O
→
7,8-dihydroneopterin 3'-phosphate H+ diphosphate
No mapped protein

H2NTPEPIM-RXN

EC 5.1.99.7 · R11082 · H2NTPEPIM-RXN · not reversible

producing
7,8-dihydroneopterin 3'-triphosphate
→
7,8-dihydromonapterin triphosphate
VK055_4822

H2PTEROATESYNTH-RXN

EC 2.5.1.15 · R03067 · H2PTEROATESYNTH-RXN · not reversible

both
(7,8-dihydropterin-6-yl)methyl diphosphate 4-aminobenzoate
→
7,8-dihydropteroate diphosphate
VK055_3890

PABASYN-RXN

EC 2.6.1.85 · R01716 · PABASYN-RXN · not reversible

L-glutamine chorismate
→
4-amino-4-deoxychorismate L-glutamate
VK055_0122

RXN0-6367

EC 1.5.1.50 · R11019 · RXN0-6367 · not reversible

7,8-dihydromonapterin H+ NADPH
→
5,6,7,8-tetrahydromonapterin NADP+
No mapped protein

RXN-8340

EC 4.1.99.22 · R09394 · RXN-8340 · not reversible

S-adenosyl-L-methionine a reduced two electron carrier GTP
→
(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate 5'-deoxyadenosine L-methionine an oxidized electron carrier H+
No mapped protein

RXN-8344

EC 2.7.7.75 · R09726 · RXN-8344 · not reversible

consuming
molybdopterin ATP H+
→
adenylyl-molybdopterin diphosphate
VK055_2565