Protein profile

VK055_3322

AAA domain family protein

Genome: KpATCC43816

Gene: AIK81879.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GGS5
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Amino acids 499
Annotations 3
Features 20
PDB binders 0
Druggability 0.517

Overview

Basic information about this protein and its source genome.

Accession
VK055_3322
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK81879.1
Status
annotated
Amino acids
499
Structure source
AlphaFold + ColabFold
GO
GO:0016887 Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016787 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
89.69

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.517
Structure A0A0H3GGS5
Pocket Pocket 11
P2Rank 0.18
Structure A0A0H3GGS5
Pocket Pocket 1
ColabFold model
FPocket 0.758 · Pocket 5
P2Rank 0.175 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 112 / 4744 genomes with a hit
Normalized 0.024

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0016887 Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
  • GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
  • GO:0016787 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.

Sequence Features

Domain/signature hits from InterPro and related databases.

20 records
Show feature table
Start End DB Term Name
11 213 Pfam PF20030 MoxR domain in the MoxR-vWA-beta-propeller ternary systems
11 213 InterPro IPR045427 MoxR domain
2 498 PANTHER PTHR32204 ATPASE RAVA
38 187 SMART SM00382 AAA_5
38 187 InterPro IPR003593 AAA+ ATPase domain
288 493 Gene3D G3DSA:1.20.58.1510 -
331 442 Gene3D G3DSA:2.40.128.430 -
331 442 InterPro IPR046932 ATPase RavA, LARA domain superfamily
23 175 CDD cd00009 AAA
228 295 Pfam PF17868 AAA lid domain
228 295 InterPro IPR041538 ATPase RavA-like, AAA lid domain
1 221 Gene3D G3DSA:3.40.50.300 -
1 221 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
22 289 SUPERFAMILY SSF52540 P-loop containing nucleoside triphosphate hydrolases
22 289 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
444 498 Pfam PF12592 ATPase, RavA, C-terminal
444 498 InterPro IPR022547 ATPase, RavA, C-terminal
1 221 FunFam G3DSA:3.40.50.300:FF:000410 ATPase RavA
335 436 Pfam PF20265 ATPase, RavA, LARA domain
335 436 InterPro IPR046898 ATPase RavA, LARA domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GGS5
AlphaFold — — full sequence — Viewing
ColabFold VK055_3322
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
4 0.158
14 0.024
15 0.004
3 0.002

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 4.89 0.18
2 2.7 0.065
3 2.16 0.042
4 2.12 0.04
5 1.72 0.025