Protein profile

VK055_3343

phosphate ABC transporter, permease protein PstC

Genome: KpATCC43816

Gene: pstC AIK81900.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GZ28
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Amino acids 303
Annotations 5
Features 32
PDB binders 0
Druggability 0.726

Overview

Basic information about this protein and its source genome.

Accession
VK055_3343
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
pstC AIK81900.1
Status
annotated
Amino acids
303
Structure source
AlphaFold + ColabFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005315 Enables the transfer of phosphate ions from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters. GO:0006817 The directed movement of phosphate ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
94.389
DEG E-value
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
92.65

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.726
Structure A0A0H3GZ28
Pocket Pocket 5
P2Rank 0.031
Structure A0A0H3GZ28
Pocket Pocket 1
ColabFold model
FPocket 0.985 · Pocket 1
P2Rank 0.042 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 157 / 4744 genomes with a hit
Normalized 0.033

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0005315 Enables the transfer of phosphate ions from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters.
  • GO:0006817 The directed movement of phosphate ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Sequence Features

Domain/signature hits from InterPro and related databases.

32 records
Show feature table
Start End DB Term Name
96 118 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
2 300 PANTHER PTHR30425 PHOSPHATE TRANSPORT SYSTEM PERMEASE PROTEIN PST
53 84 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
226 246 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
96 120 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
59 256 CDD cd06261 TM_PBP2
59 256 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
34 52 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
5 27 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
79 290 Pfam PF00528 Binding-protein-dependent transport system inner membrane component
79 290 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
289 303 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
171 225 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
85 95 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
5 296 Gene3D G3DSA:1.10.3720.10 -
5 296 InterPro IPR035906 MetI-like superfamily
140 170 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
266 288 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
2 295 NCBIfam TIGR02138 phosphate ABC transporter permease subunit PstC
2 295 InterPro IPR011864 Phosphate ABC transporter, permease protein PstC
12 287 SUPERFAMILY SSF161098 MetI-like
12 287 InterPro IPR035906 MetI-like superfamily
121 139 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
59 289 ProSiteProfiles PS50928 ABC transporter integral membrane type-1 domain profile.
59 289 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
12 33 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
150 172 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
211 233 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
62 84 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 11 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
266 288 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
247 265 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GZ28
AlphaFold — — full sequence — Viewing
ColabFold VK055_3343
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
5 0.726
8 0.679
9 0.426
3 0.278

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 2.46 0.067
2 1.51 0.022
3 1.47 0.02