Protein profile

VK055_3358

inner-membrane protein insertion factor

Genome: KpATCC43816

Gene: AIK81915.1 oxaA Structure source: AlphaFold + ColabFold UniProt A0A0H3H4V7
Export view
Amino acids 531
Annotations 5
Features 55
PDB binders 0
Druggability 0.913

Overview

Basic information about this protein and its source genome.

Accession
VK055_3358
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK81915.1 oxaA
Status
annotated
Amino acids
531
Structure source
AlphaFold + ColabFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0032977 Binds transmembrane domain-containing proteins and mediates their integration into a membrane. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0051205 The process that results in the incorporation of a protein into a biological membrane. Incorporation in this context means having some part or covalently attached group that is inserted into the the hydrophobic region of one or both bilayers. GO:0015031 The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
27.536
Human E-value
1.89e-12
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
87.782
DEG E-value
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
87.28

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.913
Structure A0A0H3H4V7
Pocket Pocket 11
P2Rank 0.937
Structure A0A0H3H4V7
Pocket Pocket 1
ColabFold model
FPocket 0.961 · Pocket 4
P2Rank 0.854 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 155 / 4744 genomes with a hit
Normalized 0.033

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0032977 Binds transmembrane domain-containing proteins and mediates their integration into a membrane.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0051205 The process that results in the incorporation of a protein into a biological membrane. Incorporation in this context means having some part or covalently attached group that is inserted into the the hydrophobic region of one or both bilayers.
  • GO:0015031 The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

Sequence Features

Domain/signature hits from InterPro and related databases.

55 records
Show feature table
Start End DB Term Name
333 355 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
38 318 Gene3D G3DSA:2.70.98.90 -
38 318 InterPro IPR038221 YidC, periplasmic domain superfamily
140 160 PRINTS PR00701 60kDa inner membrane protein signature
140 160 InterPro IPR001708 Membrane insertase YidC/ALB3/OXA1/COX18
307 327 PRINTS PR00701 60kDa inner membrane protein signature
307 327 InterPro IPR001708 Membrane insertase YidC/ALB3/OXA1/COX18
445 467 PRINTS PR00701 60kDa inner membrane protein signature
445 467 InterPro IPR001708 Membrane insertase YidC/ALB3/OXA1/COX18
482 505 PRINTS PR00701 60kDa inner membrane protein signature
482 505 InterPro IPR001708 Membrane insertase YidC/ALB3/OXA1/COX18
200 218 PRINTS PR00701 60kDa inner membrane protein signature
200 218 InterPro IPR001708 Membrane insertase YidC/ALB3/OXA1/COX18
234 249 PRINTS PR00701 60kDa inner membrane protein signature
234 249 InterPro IPR001708 Membrane insertase YidC/ALB3/OXA1/COX18
398 421 PRINTS PR00701 60kDa inner membrane protein signature
398 421 InterPro IPR001708 Membrane insertase YidC/ALB3/OXA1/COX18
48 69 PRINTS PR00701 60kDa inner membrane protein signature
48 69 InterPro IPR001708 Membrane insertase YidC/ALB3/OXA1/COX18
1 33 MobiDBLite mobidb-lite consensus disorder prediction
1 335 NCBIfam TIGR03593 membrane protein insertase, YidC/Oxa1 family, N-terminal domain
1 335 InterPro IPR028053 Membrane insertase YidC, N-terminal
1 336 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
357 399 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
38 318 FunFam G3DSA:2.70.98.90:FF:000001 Membrane protein insertase YidC
336 516 NCBIfam TIGR03592 membrane protein insertase YidC
336 516 InterPro IPR028055 Membrane insertase YidC/Oxa/ALB, C-terminal
337 516 Pfam PF02096 60Kd inner membrane protein
337 516 InterPro IPR028055 Membrane insertase YidC/Oxa/ALB, C-terminal
480 502 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
477 502 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
400 422 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
400 423 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
447 465 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
466 476 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
8 30 MobiDBLite mobidb-lite consensus disorder prediction
41 313 CDD cd19961 EcYidC-like_peri
41 313 InterPro IPR028053 Membrane insertase YidC, N-terminal
471 495 PRINTS PR01900 YidC translocation/secretion protein signature
471 495 InterPro IPR001708 Membrane insertase YidC/ALB3/OXA1/COX18
322 338 PRINTS PR01900 YidC translocation/secretion protein signature
322 338 InterPro IPR001708 Membrane insertase YidC/ALB3/OXA1/COX18
451 466 PRINTS PR01900 YidC translocation/secretion protein signature
451 466 InterPro IPR001708 Membrane insertase YidC/ALB3/OXA1/COX18
15 518 Hamap MF_01810 Membrane protein insertase YidC [yidC].
15 518 InterPro IPR019998 Membrane insertase YidC
295 521 PANTHER PTHR12428 OXA1
295 521 InterPro IPR001708 Membrane insertase YidC/ALB3/OXA1/COX18
43 326 Pfam PF14849 YidC periplasmic domain
43 326 InterPro IPR028053 Membrane insertase YidC, N-terminal
424 446 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
338 516 CDD cd20070 5TM_YidC_Alb3
338 516 InterPro IPR047196 Membrane insertase YidC/ALB, C-terminal
503 531 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
337 356 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3H4V7
AlphaFold — — full sequence — Viewing
ColabFold VK055_3358
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
11 0.913

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 26.47 0.914
2 5.47 0.261
3 3.13 0.106
4 2.21 0.053
5 2.12 0.049