Protein profile

VK055_3372

hypothetical protein

Genome: KpATCC43816

Gene: AIK81929.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GXQ8
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Amino acids 110
Annotations 0
Features 11
PDB binders 0
Druggability 0.286

Overview

Basic information about this protein and its source genome.

Accession
VK055_3372
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK81929.1
Status
annotated
Amino acids
110
Structure source
AlphaFold + ColabFold

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
34.615
Localization
Unknown
ColabFold pLDDT
64.82

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.286
Structure A0A0H3GXQ8
Pocket Pocket 2
P2Rank 0.128
Structure A0A0H3GXQ8
Pocket Pocket 1
ColabFold model
FPocket 0.838 · Pocket 11
P2Rank 0.102 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 70 / 4744 genomes with a hit
Normalized 0.015

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

11 records
Show feature table
Start End DB Term Name
27 110 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
22 26 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
34 76 Pfam PF07119 Protein of unknown function (DUF1375)
34 76 InterPro IPR010780 Protein of unknown function DUF1375
9 21 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
1 21 SignalP_EUK SignalP-noTM SignalP-noTM
1 21 ProSiteProfiles PS51257 Prokaryotic membrane lipoprotein lipid attachment site profile.
1 26 SignalP_GRAM_NEGATIVE SignalP-noTM SignalP-noTM
1 8 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
1 26 Phobius SIGNAL_PEPTIDE Signal peptide region
1 24 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GXQ8
AlphaFold — — full sequence — Viewing
ColabFold VK055_3372
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.286
5 0.255
1 0.242
9 0.073

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 3.97 0.128
2 1.33 0.013