Protein profile

VK055_3378

aspT/YidE/YbjL antiporter duplication domain protein

Genome: KpATCC43816

Gene: AIK81934.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3H4T9
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Amino acids 553
Annotations 3
Features 60
PDB binders 0
Druggability 0.817

Overview

Basic information about this protein and its source genome.

Accession
VK055_3378
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK81934.1
Status
annotated
Amino acids
553
Structure source
AlphaFold + ColabFold
GO
GO:0006813 The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0008324 Enables the transfer of cation from one side of a membrane to the other. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
65.455
DEG E-value
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
88.47

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.817
Structure A0A0H3H4T9
Pocket Pocket 20
P2Rank 0.772
Structure A0A0H3H4T9
Pocket Pocket 1
ColabFold model
FPocket 0.809 · Pocket 34
P2Rank 0.791 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 118 / 4744 genomes with a hit
Normalized 0.025

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0006813 The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
  • GO:0008324 Enables the transfer of cation from one side of a membrane to the other.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Sequence Features

Domain/signature hits from InterPro and related databases.

60 records
Show feature table
Start End DB Term Name
533 552 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
492 513 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
486 491 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
160 182 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
67 86 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
87 92 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
463 485 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
162 182 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
61 83 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
352 372 Coils Coil Coil
23 28 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
90 112 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
403 425 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
116 161 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
553 553 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
392 402 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
28 46 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
288 361 Gene3D G3DSA:3.30.70.1450 -
288 361 InterPro IPR036721 Regulator of K+ conductance, C-terminal domain superfamily
11 179 Pfam PF06826 Predicted Permease Membrane Region
11 179 InterPro IPR006512 YidE/YbjL duplication
374 546 Pfam PF06826 Predicted Permease Membrane Region
374 546 InterPro IPR006512 YidE/YbjL duplication
286 360 SUPERFAMILY SSF116726 TrkA C-terminal domain-like
286 360 InterPro IPR036721 Regulator of K+ conductance, C-terminal domain superfamily
6 22 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
459 463 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
29 47 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
48 66 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
437 459 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
426 436 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
279 361 ProSiteProfiles PS51202 RCK C-terminal domain profile.
279 361 InterPro IPR006037 Regulator of K+ conductance, C-terminal
464 485 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
15 551 PANTHER PTHR30445 UNCHARACTERIZED
4 21 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
205 272 Gene3D G3DSA:3.30.70.1450 -
205 272 InterPro IPR036721 Regulator of K+ conductance, C-terminal domain superfamily
437 458 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
93 115 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
371 393 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
403 425 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
203 271 SUPERFAMILY SSF116726 TrkA C-terminal domain-like
203 271 InterPro IPR036721 Regulator of K+ conductance, C-terminal domain superfamily
492 514 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 553 Hamap MF_01016 Putative transport protein YidE [yidE].
1 553 InterPro IPR023018 Transport protein YidE, putative
1 5 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
514 532 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
292 360 Pfam PF02080 TrkA-C domain
292 360 InterPro IPR006037 Regulator of K+ conductance, C-terminal
183 370 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
192 276 ProSiteProfiles PS51202 RCK C-terminal domain profile.
192 276 InterPro IPR006037 Regulator of K+ conductance, C-terminal
371 391 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
16 166 NCBIfam TIGR01625 AspT/YidE/YbjL antiporter duplication domain
16 166 InterPro IPR006512 YidE/YbjL duplication
379 533 NCBIfam TIGR01625 AspT/YidE/YbjL antiporter duplication domain
379 533 InterPro IPR006512 YidE/YbjL duplication
529 551 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3H4T9
AlphaFold — — full sequence — Viewing
ColabFold VK055_3378
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
20 0.817
33 0.395
25 0.375
13 0.226

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 14.55 0.726
2 4.66 0.203
3 4.47 0.19
4 3.7 0.141
5 3.66 0.138