Protein profile

VK055_3398

helix-turn-helix family protein

Genome: KpATCC43816

Gene: AIK81955.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3H0D8
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Amino acids 75
Annotations 1
Features 12
PDB binders 0
Druggability 0.195

Overview

Basic information about this protein and its source genome.

Accession
VK055_3398
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK81955.1
Status
annotated
Amino acids
75
Structure source
AlphaFold + ColabFold
GO
GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
47.273
DEG E-value
2.74e-13
Localization
Unknown
ColabFold pLDDT
93.04

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.195
Structure A0A0H3H0D8
Pocket Pocket 3
P2Rank
Structure A0A0H3H0D8
Pocket No pockets
ColabFold model
FPocket 0.273 · Pocket 2
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 25 / 4744 genomes with a hit
Normalized 0.005

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Sequence Features

Domain/signature hits from InterPro and related databases.

12 records
Show feature table
Start End DB Term Name
20 56 CDD cd00093 HTH_XRE
20 56 InterPro IPR001387 Cro/C1-type helix-turn-helix domain
11 73 Gene3D G3DSA:1.10.260.40 -
11 73 InterPro IPR010982 Lambda repressor-like, DNA-binding domain superfamily
2 72 PANTHER PTHR36511 MERR FAMILY BACTERIAL REGULATORY PROTEIN
19 73 SMART SM00530 mbf_short4
19 73 InterPro IPR001387 Cro/C1-type helix-turn-helix domain
20 74 SUPERFAMILY SSF47413 lambda repressor-like DNA-binding domains
20 74 InterPro IPR010982 Lambda repressor-like, DNA-binding domain superfamily
20 56 ProSiteProfiles PS50943 Cro/C1-type HTH domain profile.
20 64 Pfam PF01381 Helix-turn-helix
20 64 InterPro IPR001387 Cro/C1-type helix-turn-helix domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3H0D8
AlphaFold — — full sequence — Viewing
ColabFold VK055_3398
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer