Protein profile

VK055_3430

bacterial regulatory, tetR family protein

Genome: KpATCC43816

Gene: AIK81987.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3H0A5
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Amino acids 215
Annotations 3
Features 16
PDB binders 0
Druggability 0.63

Overview

Basic information about this protein and its source genome.

Accession
VK055_3430
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK81987.1
Status
annotated
Amino acids
215
Structure source
AlphaFold + ColabFold
GO
GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0000976 Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
31.313
Localization
CytoplasmicMembrane
ColabFold pLDDT
86.71

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.63
Structure A0A0H3H0A5
Pocket Pocket 2
P2Rank 0.895
Structure A0A0H3H0A5
Pocket Pocket 1
ColabFold model
FPocket 0.492 · Pocket 13
P2Rank 0.911 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 20 / 4744 genomes with a hit
Normalized 0.004

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
  • GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
  • GO:0000976 Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.

Sequence Features

Domain/signature hits from InterPro and related databases.

16 records
Show feature table
Start End DB Term Name
30 73 Pfam PF00440 Bacterial regulatory proteins, tetR family
30 73 InterPro IPR001647 DNA-binding HTH domain, TetR-type
19 214 Gene3D G3DSA:1.10.357.10 Tetracycline Repressor, domain 2
29 42 PRINTS PR00455 TetR bacterial regulatory protein HTH signature
29 42 InterPro IPR001647 DNA-binding HTH domain, TetR-type
50 73 PRINTS PR00455 TetR bacterial regulatory protein HTH signature
50 73 InterPro IPR001647 DNA-binding HTH domain, TetR-type
18 95 SUPERFAMILY SSF46689 Homeodomain-like
18 95 InterPro IPR009057 Homeobox-like domain superfamily
23 83 ProSiteProfiles PS50977 TetR-type HTH domain profile.
23 83 InterPro IPR001647 DNA-binding HTH domain, TetR-type
12 213 PANTHER PTHR30055 HTH-TYPE TRANSCRIPTIONAL REGULATOR RUTR
1 25 MobiDBLite mobidb-lite consensus disorder prediction
8 24 MobiDBLite mobidb-lite consensus disorder prediction
96 213 SUPERFAMILY SSF48498 Tetracyclin repressor-like, C-terminal domain
96 213 InterPro IPR036271 Tetracyclin repressor-like, C-terminal domain superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3H0A5
AlphaFold — — full sequence — Viewing
ColabFold VK055_3430
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.63
1 0.0
12 0.0
17 0.0

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 29.22 0.895
2 2.81 0.07
3 1.25 0.01
4 1.11 0.007