Protein profile

VK055_3436

cupin domain protein

Genome: KpATCC43816

Gene: AIK81993.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GUZ4
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Amino acids 301
Annotations 3
Features 25
PDB binders 0
Druggability 0.336

Overview

Basic information about this protein and its source genome.

Accession
VK055_3436
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK81993.1
Status
annotated
Amino acids
301
Structure source
AlphaFold + ColabFold
GO
GO:0043565 Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
32.955
Localization
CytoplasmicMembrane
ColabFold pLDDT
93.32

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.336
Structure A0A0H3GUZ4
Pocket Pocket 17
P2Rank 0.19
Structure A0A0H3GUZ4
Pocket Pocket 1
ColabFold model
FPocket 0.364 · Pocket 7
P2Rank 0.332 · Pocket 1
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 16 / 4744 genomes with a hit
Normalized 0.003

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0043565 Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
  • GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

Sequence Features

Domain/signature hits from InterPro and related databases.

25 records
Show feature table
Start End DB Term Name
252 295 ProSitePatterns PS00041 Bacterial regulatory proteins, araC family signature.
252 295 InterPro IPR018062 HTH domain AraC-type, conserved site
257 301 Gene3D G3DSA:1.10.10.60 -
2 182 Pfam PF12852 Cupin
2 182 InterPro IPR032783 AraC-type transcription regulator, ligand-binding domain
199 256 Gene3D G3DSA:1.10.10.60 -
221 300 Pfam PF12833 Helix-turn-helix domain
221 300 InterPro IPR018060 DNA binding HTH domain, AraC-type
199 301 ProSiteProfiles PS01124 Bacterial regulatory proteins, araC family DNA-binding domain profile.
199 301 InterPro IPR018060 DNA binding HTH domain, AraC-type
33 300 PANTHER PTHR46796 HTH-TYPE TRANSCRIPTIONAL ACTIVATOR RHAS-RELATED
215 299 SMART SM00342 aracneu4
215 299 InterPro IPR018060 DNA binding HTH domain, AraC-type
198 248 SUPERFAMILY SSF46689 Homeodomain-like
198 248 InterPro IPR009057 Homeobox-like domain superfamily
24 84 SUPERFAMILY SSF51182 RmlC-like cupins
24 84 InterPro IPR011051 RmlC-like cupin domain superfamily
251 300 SUPERFAMILY SSF46689 Homeodomain-like
251 300 InterPro IPR009057 Homeobox-like domain superfamily
31 81 Gene3D G3DSA:2.60.120.10 Jelly Rolls
31 81 InterPro IPR014710 RmlC-like jelly roll fold
283 299 PRINTS PR00032 AraC bacterial regulatory protein HTH signature
283 299 InterPro IPR020449 Transcription regulator HTH, AraC- type
268 283 PRINTS PR00032 AraC bacterial regulatory protein HTH signature
268 283 InterPro IPR020449 Transcription regulator HTH, AraC- type

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GUZ4
AlphaFold — — full sequence — Viewing
ColabFold VK055_3436
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
3 0.253
1 0.142
7 0.008
2 0.0

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 5.05 0.19
2 3.85 0.121
3 2.54 0.058
4 2.16 0.042
5 1.8 0.028