Protein profile

VK055_3466

ferredoxin-NADP reductase

Genome: KpATCC43816

Gene: fpr AIK82022.1 Structure source: Experimental + ColabFold UniProt A0A0G3NED2
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Amino acids 248
Annotations 9
Features 18
PDB binders 2
Druggability 0.943

Overview

Basic information about this protein and its source genome.

Accession
VK055_3466
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
fpr AIK82022.1
Status
annotated
Amino acids
248
Structure source
Experimental + ColabFold
EC
1.18.1.2 1.19.1.1
GO
GO:0004324 Catalysis of the reaction: 2 reduced [2Fe-2S]-[ferredoxin] + NADP+ + H+ = 2 oxidized [2Fe-2S]-[ferredoxin] + NADPH. GO:0016491 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0046872 Binding to a metal ion. GO:0000166 Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose. GO:0034599 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
39.912
Localization
Cytoplasmic
ColabFold pLDDT
97.9

Selected Druggability evidence

PDB experimental structure

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.943
Structure 8DOS
Pocket Pocket 1
P2Rank 0.907
Structure 8DOS
Pocket Pocket 1
ColabFold model
FPocket 0.17 · Pocket 16
P2Rank 0.788 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 113 / 4744 genomes with a hit
Normalized 0.024

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 EC 7 GO

Enzyme Commission (EC)

2

Gene Ontology (GO)

7
  • GO:0004324 Catalysis of the reaction: 2 reduced [2Fe-2S]-[ferredoxin] + NADP+ + H+ = 2 oxidized [2Fe-2S]-[ferredoxin] + NADPH.
  • GO:0016491 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
  • GO:0046872 Binding to a metal ion.
  • GO:0000166 Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.
  • GO:0034599 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
  • GO:0042167 The chemical reactions and pathways resulting in the breakdown of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring.

Sequence Features

Domain/signature hits from InterPro and related databases.

18 records
Show feature table
Start End DB Term Name
2 101 ProSiteProfiles PS51384 Ferredoxin reductase-type FAD binding domain profile.
2 101 InterPro IPR017927 FAD-binding domain, ferredoxin reductase-type
1 248 PANTHER PTHR47878 OXIDOREDUCTASE FAD/NAD(P)-BINDING DOMAIN PROTEIN
1 96 FunFam G3DSA:2.40.30.10:FF:000044 Ferredoxin--NADP(+) reductase
8 247 CDD cd06195 FNR1
8 247 InterPro IPR033892 Ferredoxin--NADP reductase, bacteria
97 248 Gene3D G3DSA:3.40.50.80 -
97 248 InterPro IPR039261 Ferredoxin-NADP reductase (FNR), nucleotide-binding domain
20 88 Pfam PF00970 Oxidoreductase FAD-binding domain
20 88 InterPro IPR008333 Flavoprotein pyridine nucleotide cytochrome reductase-like, FAD-binding domain
3 100 SUPERFAMILY SSF63380 Riboflavin synthase domain-like
3 100 InterPro IPR017938 Riboflavin synthase-like beta-barrel
97 248 FunFam G3DSA:3.40.50.80:FF:000013 Ferredoxin--NADP(+) reductase
104 248 SUPERFAMILY SSF52343 Ferredoxin reductase-like, C-terminal NADP-linked domain
104 248 InterPro IPR039261 Ferredoxin-NADP reductase (FNR), nucleotide-binding domain
1 96 Gene3D G3DSA:2.40.30.10 Translation factors
111 222 Pfam PF00175 Oxidoreductase NAD-binding domain
111 222 InterPro IPR001433 Oxidoreductase FAD/NAD(P)-binding

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

1 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 8DOS
X-ray 1.87 Å A,B
100.0% 1-248
PDBe RCSB PDBj File
Viewing
ColabFold VK055_3466
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.762
3 0.297

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 28.89 0.928
2 27.34 0.92
3 4.25 0.175
4 2.51 0.07
5 2.36 0.062

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

13 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
FDA
1TVC
P22868 787.6 Da LogP -1.75 TPSA 363.3 3 viol. ✓ Clean Cc1cc2c(cc1C)N(C3=C(N2)C(=O)NC(=O)N3)C[C@@H]([C…
FES
1JQ4
P22868 175.8 Da LogP 1.29 TPSA 0.0 ✓ Ro5 ✓ Clean S1[Fe]S[Fe]1

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.