Protein profile

VK055_3478

hypothetical protein

Genome: KpATCC43816

Gene: AIK82034.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GXE6
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Amino acids 287
Annotations 2
Features 8
PDB binders 0
Druggability 0.742

Overview

Basic information about this protein and its source genome.

Accession
VK055_3478
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK82034.1
Status
annotated
Amino acids
287
Structure source
AlphaFold + ColabFold
GO
GO:0016787 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0004521 Catalysis of the cleavage of ester linkages within ribonucleic acid by creating internal breaks.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
64.111
DEG E-value
2.44e-135
Localization
Cytoplasmic
ColabFold pLDDT
88.36

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.742
Structure A0A0H3GXE6
Pocket Pocket 2
P2Rank
Structure A0A0H3GXE6
Pocket No pockets
ColabFold model
FPocket 0.578 · Pocket 2
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 149 / 4744 genomes with a hit
Normalized 0.031

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0016787 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
  • GO:0004521 Catalysis of the cleavage of ester linkages within ribonucleic acid by creating internal breaks.

Sequence Features

Domain/signature hits from InterPro and related databases.

8 records
Show feature table
Start End DB Term Name
182 218 Coils Coil Coil
1 287 NCBIfam TIGR00255 YicC family protein
1 287 InterPro IPR005229 UPF0701 protein YicC-like
2 153 Pfam PF03755 YicC-like family, N-terminal region
2 153 InterPro IPR013527 YicC-like, N-terminal
1 287 PANTHER PTHR30636 UNCHARACTERIZED
203 287 Pfam PF08340 Domain of unknown function (DUF1732)
203 287 InterPro IPR013551 Domain of unknown function DUF1732

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GXE6
AlphaFold — — full sequence — Viewing
ColabFold VK055_3478
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.742