Protein profile

VK055_3491

DNA repair RadC family protein

Genome: KpATCC43816

Gene: AIK82047.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3H4I9
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Amino acids 218
Annotations 3
Features 21
PDB binders 0
Druggability 0.7

Overview

Basic information about this protein and its source genome.

Accession
VK055_3491
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK82047.1
Status
annotated
Amino acids
218
Structure source
AlphaFold + ColabFold
GO
GO:0046872 Binding to a metal ion. GO:0008237 Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. GO:0006508 The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
72.558
DEG E-value
2.64e-119
Localization
Cytoplasmic
ColabFold pLDDT
91.53

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.7
Structure A0A0H3H4I9
Pocket Pocket 14
P2Rank 0.165
Structure A0A0H3H4I9
Pocket Pocket 1
ColabFold model
FPocket 0.474 · Pocket 3
P2Rank 0.191 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 133 / 4744 genomes with a hit
Normalized 0.028

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0046872 Binding to a metal ion.
  • GO:0008237 Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
  • GO:0006508 The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.

Sequence Features

Domain/signature hits from InterPro and related databases.

21 records
Show feature table
Start End DB Term Name
38 81 Gene3D G3DSA:1.10.150.20 -
167 172 ProSitePatterns PS01302 Uncharacterized protein family UPF0758 signature.
167 172 InterPro IPR020891 Uncharacterised protein family UPF0758, conserved site
95 217 Gene3D G3DSA:3.40.140.10 Cytidine Deaminase, domain 2
5 218 NCBIfam TIGR00608 DNA repair protein RadC
5 218 InterPro IPR001405 Uncharacterised protein family UPF0758
96 218 ProSiteProfiles PS50249 MPN domain profile.
96 218 InterPro IPR037518 MPN domain
99 216 Pfam PF04002 RadC-like JAB domain
99 216 InterPro IPR025657 RadC-like JAB domain
2 218 Hamap MF_00018 UPF0758 protein YicR [yicR].
2 218 InterPro IPR022820 Uncharacterised protein family UPF0758, YicR subfamily
147 183 SUPERFAMILY SSF102712 JAB1/MPN domain
104 213 CDD cd08071 MPN_DUF2466
104 213 InterPro IPR025657 RadC-like JAB domain
14 81 SUPERFAMILY SSF47781 RuvA domain 2-like
14 81 InterPro IPR010994 RuvA domain 2-like
2 218 PANTHER PTHR30471 DNA REPAIR PROTEIN RADC
2 218 InterPro IPR001405 Uncharacterised protein family UPF0758
5 74 Pfam PF20582 UPF0758 N-terminal
5 74 InterPro IPR046778 UPF0758, N-terminal

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3H4I9
AlphaFold — — full sequence — Viewing
ColabFold VK055_3491
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
14 0.7
1 0.562
7 0.217

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 2.96 0.096
2 1.65 0.027