Protein profile

VK055_3499

glycosyl transferases group 1 family protein

Genome: KpATCC43816

Gene: AIK82055.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3H044
Export view
Amino acids 364
Annotations 2
Features 10
PDB binders 1
Druggability 0.225

Overview

Basic information about this protein and its source genome.

Accession
VK055_3499
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK82055.1
Status
annotated
Amino acids
364
Structure source
AlphaFold + ColabFold
GO
GO:0016757 Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). GO:1901135 The chemical reactions and pathways involving carbohydrate derivative.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
29.412
Localization
Cytoplasmic
ColabFold pLDDT
93.71

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.225
Structure A0A0H3H044
Pocket Pocket 22
P2Rank 0.859
Structure A0A0H3H044
Pocket Pocket 1
ColabFold model
FPocket 0.202 · Pocket 1
P2Rank 0.78 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 34 / 4744 genomes with a hit
Normalized 0.007

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0016757 Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor).
  • GO:1901135 The chemical reactions and pathways involving carbohydrate derivative.

Sequence Features

Domain/signature hits from InterPro and related databases.

10 records
Show feature table
Start End DB Term Name
197 337 Pfam PF00534 Glycosyl transferases group 1
197 337 InterPro IPR001296 Glycosyl transferase, family 1
1 193 Gene3D G3DSA:3.40.50.2000 Glycogen Phosphorylase B;
2 361 SUPERFAMILY SSF53756 UDP-Glycosyltransferase/glycogen phosphorylase
2 360 CDD cd03811 GT4_GT28_WabH-like
66 86 Coils Coil Coil
194 353 Gene3D G3DSA:3.40.50.2000 Glycogen Phosphorylase B;
13 182 Pfam PF13439 Glycosyltransferase Family 4
13 182 InterPro IPR028098 Glycosyltransferase subfamily 4-like, N-terminal domain
1 319 PANTHER PTHR12526 GLYCOSYLTRANSFERASE

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3H044
AlphaFold — — full sequence — Viewing
ColabFold VK055_3499
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
22 0.225

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 7.71 0.408
2 3.7 0.14
3 2.8 0.086
4 1.88 0.037
5 1.84 0.036

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

7 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
MLT
3MBO
Q81ST7 134.1 Da LogP -1.09 TPSA 94.8 ✓ Ro5 ✓ Clean C([C@H](C(=O)O)O)C(=O)O

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.