Protein profile

VK055_3525

mannitol operon repressor

Genome: KpATCC43816

Gene: AIK82082.1 Structure source: AlphaFold + ColabFold UniProt A0A919LXB9
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Amino acids 178
Annotations 1
Features 7
PDB binders 0
Druggability 0.222

Overview

Basic information about this protein and its source genome.

Accession
VK055_3525
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK82082.1
Status
annotated
Amino acids
178
Structure source
AlphaFold + ColabFold
GO
GO:0045892 Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
90.81

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.222
Structure A0A919LXB9
Pocket Pocket 6
P2Rank
Structure A0A919LXB9
Pocket No pockets
ColabFold model
FPocket 0.314 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 96 / 4744 genomes with a hit
Normalized 0.02

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0045892 Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.

Sequence Features

Domain/signature hits from InterPro and related databases.

7 records
Show feature table
Start End DB Term Name
6 167 SUPERFAMILY SSF158668 MtlR-like
6 167 InterPro IPR038026 MtlR-like superfamily
2 173 PANTHER PTHR37941 FUMARASE E-RELATED
2 173 InterPro IPR007761 Mannitol repressor MtlR-like
9 167 Pfam PF05068 Mannitol repressor
9 167 InterPro IPR007761 Mannitol repressor MtlR-like
2 168 Gene3D G3DSA:1.20.120.330 Nucleotidyltransferases domain 2

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A919LXB9
AlphaFold — — full sequence — Viewing
ColabFold VK055_3525
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
6 0.222