Protein profile

VK055_3596

H+ symporter family protein

Genome: KpATCC43816

Gene: AIK82151.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GYM1
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Amino acids 440
Annotations 4
Features 52
PDB binders 0
Druggability 0.659

Overview

Basic information about this protein and its source genome.

Accession
VK055_3596
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK82151.1
Status
annotated
Amino acids
440
Structure source
AlphaFold + ColabFold
GO
GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
23.385
Human E-value
5.68e-06
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
46.469
DEG E-value
6.79e-111
Localization
CytoplasmicMembrane
ColabFold pLDDT
91.07

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.659
Structure A0A0H3GYM1
Pocket Pocket 2
P2Rank 0.892
Structure A0A0H3GYM1
Pocket Pocket 1
ColabFold model
FPocket 0.85 · Pocket 3
P2Rank 0.877 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 163 / 4744 genomes with a hit
Normalized 0.034

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Sequence Features

Domain/signature hits from InterPro and related databases.

52 records
Show feature table
Start End DB Term Name
271 289 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
308 325 ProSitePatterns PS00216 Sugar transport proteins signature 1.
308 325 InterPro IPR005829 Sugar transporter, conserved site
409 431 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
19 439 SUPERFAMILY SSF103473 MFS general substrate transporter
19 439 InterPro IPR036259 MFS transporter superfamily
24 46 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
410 432 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
245 439 FunFam G3DSA:1.20.1250.20:FF:000114 Inner membrane metabolite transporter yhjE
267 434 Pfam PF07690 Major Facilitator Superfamily
267 434 InterPro IPR011701 Major facilitator superfamily
55 65 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
383 405 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
249 270 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 37 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
247 269 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
346 370 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
66 88 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
95 117 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
290 312 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
30 426 NCBIfam TIGR00883 metabolite/H+ symporter
30 426 InterPro IPR004736 MFS transporter, metabolite:H symporter
167 189 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
346 368 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
66 85 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
38 54 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
371 381 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
200 217 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
24 226 Pfam PF00083 Sugar (and other) transporter
24 226 InterPro IPR005828 Major facilitator, sugar transporter-like
341 345 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
8 439 PANTHER PTHR43045 SHIKIMATE TRANSPORTER
189 199 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
97 117 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
20 237 FunFam G3DSA:1.20.1250.20:FF:000001 Dicarboxylate MFS transporter
218 248 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
313 320 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
382 403 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
196 218 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
118 167 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
20 440 Gene3D G3DSA:1.20.1250.20 MFS general substrate transporter like domains
20 440 InterPro IPR036259 MFS transporter superfamily
322 341 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
86 96 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
23 437 ProSiteProfiles PS50850 Major facilitator superfamily (MFS) profile.
23 437 InterPro IPR020846 Major facilitator superfamily domain
404 408 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
432 440 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
168 188 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
22 417 CDD cd17369 MFS_ShiA_like
290 312 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
321 340 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GYM1
AlphaFold — — full sequence — Viewing
ColabFold VK055_3596
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.535
24 0.008
14 0.0
18 0.0

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 28.85 0.892
2 18.77 0.76
3 4.74 0.172
4 3.05 0.081