Protein profile

VK055_3608

SAM-dependent methyltransferase family protein

Genome: KpATCC43816

Gene: AIK82163.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GUF2
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Amino acids 250
Annotations 4
Features 13
PDB binders 0
Druggability 0.447

Overview

Basic information about this protein and its source genome.

Accession
VK055_3608
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK82163.1
Status
annotated
Amino acids
250
Structure source
AlphaFold + ColabFold
EC
2.1.1.242
GO
GO:0031167 The posttranscriptional addition of methyl groups to specific residues in an rRNA molecule. GO:0008990 Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N2-methylguanine. GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
69.048
DEG E-value
2.27e-12
Localization
Unknown
ColabFold pLDDT
94.59

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.447
Structure A0A0H3GUF2
Pocket Pocket 2
P2Rank 0.694
Structure A0A0H3GUF2
Pocket Pocket 1
ColabFold model
FPocket 0.404 · Pocket 3
P2Rank 0.701 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 152 / 4744 genomes with a hit
Normalized 0.032

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 3 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

3
  • GO:0031167 The posttranscriptional addition of methyl groups to specific residues in an rRNA molecule.
  • GO:0008990 Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N2-methylguanine.
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

Sequence Features

Domain/signature hits from InterPro and related databases.

13 records
Show feature table
Start End DB Term Name
8 246 SUPERFAMILY SSF53335 S-adenosyl-L-methionine-dependent methyltransferases
8 246 InterPro IPR029063 S-adenosyl-L-methionine-dependent methyltransferase superfamily
2 247 PANTHER PTHR36112 RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE J
2 247 InterPro IPR007536 Ribosomal RNA small subunit methyltransferase J
3 248 Hamap MF_01523 Ribosomal RNA small subunit methyltransferase J [rsmJ].
3 248 InterPro IPR007536 Ribosomal RNA small subunit methyltransferase J
19 246 Pfam PF04445 Putative SAM-dependent methyltransferase
19 246 InterPro IPR007536 Ribosomal RNA small subunit methyltransferase J
57 249 FunFam G3DSA:3.40.50.150:FF:000072 Ribosomal RNA small subunit methyltransferase J
91 176 CDD cd02440 AdoMet_MTases
1 56 Gene3D G3DSA:3.40.1630.10 -
57 249 Gene3D G3DSA:3.40.50.150 Vaccinia Virus protein VP39
57 249 InterPro IPR029063 S-adenosyl-L-methionine-dependent methyltransferase superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GUF2
AlphaFold — — full sequence — Viewing
ColabFold VK055_3608
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.447
6 0.062
1 0.04
5 0.001

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 16.18 0.694
2 2.69 0.065
3 1.9 0.032