Protein profile

VK055_3699

molecular chaperone Hsp33

Genome: KpATCC43816

Gene: AIK82254.1 hslO Structure source: AlphaFold + ColabFold UniProt A0A0H3GZF6
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Amino acids 292
Annotations 5
Features 20
PDB binders 0
Druggability 0.294

Overview

Basic information about this protein and its source genome.

Accession
VK055_3699
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK82254.1 hslO
Status
annotated
Amino acids
292
Structure source
AlphaFold + ColabFold
GO
GO:0006457 The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. GO:0051082 Binding to an unfolded protein. GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0044183 Binding to a protein or a protein-containing complex to assist the protein folding process. GO:0042026 The process carried out by a cell that restores the biological activity of an unfolded or misfolded protein, using helper proteins such as chaperones.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
57.5
DEG E-value
5.07e-118
Localization
Cytoplasmic
ColabFold pLDDT
91.8

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.294
Structure A0A0H3GZF6
Pocket Pocket 9
P2Rank 0.138
Structure A0A0H3GZF6
Pocket Pocket 1
ColabFold model
FPocket 0.123 · Pocket 3
P2Rank 0.12 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 144 / 4744 genomes with a hit
Normalized 0.03

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0006457 The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.
  • GO:0051082 Binding to an unfolded protein.
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
  • GO:0044183 Binding to a protein or a protein-containing complex to assist the protein folding process.
  • GO:0042026 The process carried out by a cell that restores the biological activity of an unfolded or misfolded protein, using helper proteins such as chaperones.

Sequence Features

Domain/signature hits from InterPro and related databases.

20 records
Show feature table
Start End DB Term Name
226 285 Gene3D G3DSA:3.90.1280.10 -
226 285 InterPro IPR016154 Heat shock protein Hsp33, C-terminal
4 232 SUPERFAMILY SSF64397 Hsp33 domain
4 232 InterPro IPR016153 Heat shock protein Hsp33, N-terminal
7 273 CDD cd00498 Hsp33
7 273 InterPro IPR000397 Heat shock protein Hsp33
5 272 Pfam PF01430 Hsp33 protein
5 272 InterPro IPR000397 Heat shock protein Hsp33
1 285 PIRSF PIRSF005261 HSP33
1 285 InterPro IPR000397 Heat shock protein Hsp33
4 284 Hamap MF_00117 33 kDa chaperonin [hslO].
4 284 InterPro IPR000397 Heat shock protein Hsp33
3 287 PANTHER PTHR30111 33 KDA CHAPERONIN
3 287 InterPro IPR000397 Heat shock protein Hsp33
177 225 Gene3D G3DSA:1.10.287.480 helix hairpin bin
177 225 InterPro IPR023212 Heat shock protein Hsp33, helix hairpin bin domain superfamily
225 283 SUPERFAMILY SSF118352 HSP33 redox switch-like
225 283 InterPro IPR016154 Heat shock protein Hsp33, C-terminal
1 176 Gene3D G3DSA:3.55.30.10 Hsp33 domain
1 176 InterPro IPR016153 Heat shock protein Hsp33, N-terminal

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GZF6
AlphaFold — — full sequence — Viewing
ColabFold VK055_3699
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.285
12 0.094
10 0.052
8 0.007

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 4.15 0.138
2 4.0 0.13
3 0.88 0.003