Protein profile

VK055_3702

intracellular growth attenuator IgaA family protein

Genome: KpATCC43816

Gene: AIK82257.1 Structure source: Experimental + AlphaFold + ColabFold UniProt A0A0H3GWS2
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Amino acids 709
Annotations 2
Features 18
PDB binders 0
Druggability 0.876

Overview

Basic information about this protein and its source genome.

Accession
VK055_3702
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK82257.1
Status
annotated
Amino acids
709
Structure source
Experimental + AlphaFold + ColabFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
72.599
DEG E-value
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
82.68

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.876
Structure A0A0H3GWS2
Pocket Pocket 80
P2Rank 0.765
Structure A0A0H3GWS2
Pocket Pocket 1
ColabFold model
FPocket 0.741 · Pocket 10
P2Rank 0.599 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 88 / 4744 genomes with a hit
Normalized 0.019

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Sequence Features

Domain/signature hits from InterPro and related databases.

18 records
Show feature table
Start End DB Term Name
225 245 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
651 673 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
220 224 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
23 200 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
651 673 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
4 21 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
201 219 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
358 650 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
228 245 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
674 709 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
246 334 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
335 357 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 5 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 703 Pfam PF07095 Intracellular growth attenuator protein IgaA
1 703 InterPro IPR010771 Intracellular growth attenuator IgaA
335 357 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
205 224 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
6 22 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

1 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 9BIZ
X-ray 2.50 Å A
38.5% 373-645
PDBe RCSB PDBj File
Viewing
AlphaFold AF_A0A0H3GWS2
AlphaFold — — full sequence — Loaded
ColabFold VK055_3702
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
10 0.451
2 0.435
8 0.342
4 0.302

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 1.46 0.02