Protein profile

VK055_3746

sulfur relay protein TusB/DsrH

Genome: KpATCC43816

Gene: AIK82301.1 dsrH Structure source: AlphaFold + ColabFold UniProt A0A0H3GZB8
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Amino acids 75
Annotations 3
Features 9
PDB binders 0
Druggability 0.181

Overview

Basic information about this protein and its source genome.

Accession
VK055_3746
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK82301.1 dsrH
Status
annotated
Amino acids
75
Structure source
AlphaFold + ColabFold
GO
GO:0002143 The process in which a uridine residue at position 34 in the anticodon of a tRNA is post-transcriptionally thiolated at the C2 position. This process involves transfer of a sulfur from cysteine to position C2 by several steps. GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:1990228 A protein complex capable of catalyzing the transfer of sulfur atoms from one compound (donor) to another (acceptor).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
57.333
DEG E-value
1.0400000000000002e-27
Localization
Unknown
ColabFold pLDDT
96.06

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.181
Structure A0A0H3GZB8
Pocket Pocket 3
P2Rank
Structure A0A0H3GZB8
Pocket No pockets
ColabFold model
FPocket 0.141 · Pocket 1
P2Rank 0.02 · Pocket 1
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 76 / 4744 genomes with a hit
Normalized 0.016

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0002143 The process in which a uridine residue at position 34 in the anticodon of a tRNA is post-transcriptionally thiolated at the C2 position. This process involves transfer of a sulfur from cysteine to position C2 by several steps.
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
  • GO:1990228 A protein complex capable of catalyzing the transfer of sulfur atoms from one compound (donor) to another (acceptor).

Sequence Features

Domain/signature hits from InterPro and related databases.

9 records
Show feature table
Start End DB Term Name
1 75 Gene3D G3DSA:3.40.1260.10 -
1 75 InterPro IPR027396 DsrEFH-like
2 75 NCBIfam TIGR03011 sulfurtransferase complex subunit TusB
2 75 InterPro IPR007215 Sulphur relay, TusB/DsrH
2 75 PANTHER PTHR37526 PROTEIN TUSB
2 75 SUPERFAMILY SSF75169 DsrEFH-like
2 75 InterPro IPR027396 DsrEFH-like
2 70 Pfam PF04077 DsrH like protein
2 70 InterPro IPR007215 Sulphur relay, TusB/DsrH

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

No pockets are loaded yet for the displayed AlphaFold model AF_A0A0H3GZB8 structure. Run experimental pocket backfill to show FPocket/P2Rank overlays on this structure.

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GZB8
AlphaFold — — full sequence — Viewing
ColabFold VK055_3746
ColabFold — — full sequence — Loaded