Protein profile

VK055_3803

acrA Membrane Fusion Protein

Genome: KpATCC43816

Gene: AIK82353.1 acrA2 Structure source: AlphaFold + ColabFold UniProt A0A0H3H3T2
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Amino acids 379
Annotations 3
Features 22
PDB binders 0
Druggability 0.913

Overview

Basic information about this protein and its source genome.

Accession
VK055_3803
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK82353.1 acrA2
Status
annotated
Amino acids
379
Structure source
AlphaFold + ColabFold
GO
GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
70.321
DEG E-value
6.670000000000001e-167
Localization
CytoplasmicMembrane
ColabFold pLDDT
86.25

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.913
Structure A0A0H3H3T2
Pocket Pocket 1
P2Rank 0.091
Structure A0A0H3H3T2
Pocket Pocket 1
ColabFold model
FPocket 0.505 · Pocket 4
P2Rank 0.036 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 143 / 4744 genomes with a hit
Normalized 0.03

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

Sequence Features

Domain/signature hits from InterPro and related databases.

22 records
Show feature table
Start End DB Term Name
279 370 Gene3D G3DSA:2.40.420.20 -
26 379 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 25 Phobius SIGNAL_PEPTIDE Signal peptide region
7 20 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
1 23 ProSiteProfiles PS51257 Prokaryotic membrane lipoprotein lipid attachment site profile.
1 28 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
97 170 FunFam G3DSA:1.10.287.470:FF:000002 Efflux RND transporter periplasmic adaptor subunit
7 374 PANTHER PTHR30158 ACRA/E-RELATED COMPONENT OF DRUG EFFLUX TRANSPORTER
56 278 Gene3D G3DSA:2.40.30.170 -
288 354 Pfam PF00529 Cation efflux system protein CusB domain 1
288 354 InterPro IPR043602 Cation efflux system protein CusB, domain 1
1 6 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
1 25 SignalP_EUK SignalP-noTM SignalP-noTM
61 287 Pfam PF16576 Barrel-sandwich domain of CusB or HlyD membrane-fusion
61 287 InterPro IPR032317 RND efflux pump, membrane fusion protein, barrel-sandwich domain
97 170 Gene3D G3DSA:1.10.287.470 Helix hairpin bin
278 370 FunFam G3DSA:2.40.420.20:FF:000001 Efflux RND transporter periplasmic adaptor subunit
38 369 NCBIfam TIGR01730 efflux RND transporter periplasmic adaptor subunit
38 369 InterPro IPR006143 RND efflux pump, membrane fusion protein
50 294 SUPERFAMILY SSF111369 HlyD-like secretion proteins
21 25 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
62 206 Gene3D G3DSA:2.40.50.100 -

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3H3T2
AlphaFold — — full sequence — Viewing
ColabFold VK055_3803
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.913

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 2.48 0.068