Protein profile

VK055_3827

aaeAB Hydroxylated, Aromatic Carboxylic Acid Efflux Transport System Protein A

Genome: KpATCC43816

Gene: AIK82377.1 aaeA Structure source: AlphaFold + ColabFold UniProt A0A0H3H3P2
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Amino acids 296
Annotations 3
Features 17
PDB binders 0
Druggability 0.086

Overview

Basic information about this protein and its source genome.

Accession
VK055_3827
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK82377.1 aaeA
Status
annotated
Amino acids
296
Structure source
AlphaFold + ColabFold
GO
GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
28.378
Localization
CytoplasmicMembrane
ColabFold pLDDT
89.32

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.086
Structure A0A0H3H3P2
Pocket Pocket 20
P2Rank 0.144
Structure A0A0H3H3P2
Pocket Pocket 1
ColabFold model
FPocket 0.864 · Pocket 2
P2Rank 0.177 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 94 / 4744 genomes with a hit
Normalized 0.02

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

Sequence Features

Domain/signature hits from InterPro and related databases.

17 records
Show feature table
Start End DB Term Name
2 283 PANTHER PTHR30367 P-HYDROXYBENZOIC ACID EFFLUX PUMP SUBUNIT AAEA-RELATED
110 130 Coils Coil Coil
17 296 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
156 281 Gene3D G3DSA:2.40.30.170 -
2 12 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
32 226 NCBIfam TIGR01730 efflux RND transporter periplasmic adaptor subunit
32 226 InterPro IPR006143 RND efflux pump, membrane fusion protein
34 80 Pfam PF13533 Biotin-lipoyl like
34 80 InterPro IPR039562 Membrane fusion protein, biotin-lipoyl like domain
13 16 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
33 104 Gene3D G3DSA:2.40.50.100 -
1 1 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
1 296 Hamap MF_01544 p-hydroxybenzoic acid efflux pump subunit AaeA [aaeA].
1 296 InterPro IPR022871 Para-hydroxybenzoic acid efflux pump, subunit AaeA
142 227 Pfam PF13437 HlyD family secretion protein
32 202 SUPERFAMILY SSF111369 HlyD-like secretion proteins
1 16 Phobius SIGNAL_PEPTIDE Signal peptide region

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3H3P2
AlphaFold — — full sequence — Viewing
ColabFold VK055_3827
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer