Protein profile

VK055_3845

hypothetical protein

Genome: KpATCC43816

Gene: AIK82395.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GTU9
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Amino acids 132
Annotations 3
Features 11
PDB binders 0
Druggability 0.85

Overview

Basic information about this protein and its source genome.

Accession
VK055_3845
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK82395.1
Status
annotated
Amino acids
132
Structure source
AlphaFold + ColabFold
GO
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0051301 The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. GO:0008360 Any process that modulates the surface configuration of a cell.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
92.424
DEG E-value
1.12e-88
Localization
CytoplasmicMembrane
ColabFold pLDDT
80.44

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.85
Structure A0A0H3GTU9
Pocket Pocket 15
P2Rank
Structure A0A0H3GTU9
Pocket No pockets
ColabFold model
FPocket 0.332 · Pocket 13
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 113 / 4744 genomes with a hit
Normalized 0.024

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0051301 The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
  • GO:0008360 Any process that modulates the surface configuration of a cell.

Sequence Features

Domain/signature hits from InterPro and related databases.

11 records
Show feature table
Start End DB Term Name
1 5 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
5 24 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 132 PANTHER PTHR39579 INNER MEMBRANE PROTEIN YHCB
1 132 InterPro IPR009386 Protein of unknown function DUF1043
6 24 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
6 126 Pfam PF06295 Protein of unknown function (DUF1043)
6 126 InterPro IPR009386 Protein of unknown function DUF1043
31 58 Coils Coil Coil
25 132 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
83 132 MobiDBLite mobidb-lite consensus disorder prediction
1 132 PIRSF PIRSF006318 YhcB

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GTU9
AlphaFold — — full sequence — Viewing
ColabFold VK055_3845
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
15 0.85