Protein profile

VK055_3892

preprotein translocase, SecG subunit

Genome: KpATCC43816

Gene: secG AIK82442.1 Structure source: ColabFold
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Amino acids 89
Annotations 3
Features 17
PDB binders 0
Druggability 0.598

Overview

Basic information about this protein and its source genome.

Accession
VK055_3892
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
secG AIK82442.1
Status
annotated
Amino acids
89
Structure source
ColabFold
GO
GO:0009306 The controlled release of proteins from a cell. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015450 Primary active carrier-mediated transport of a protein across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
87.778
DEG E-value
1.4999999999999998e-52
Localization
CytoplasmicMembrane
ColabFold pLDDT
67.23

Selected Druggability evidence

ColabFold / curated model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.598
Structure CB_VK055_3892
Pocket Pocket 4
P2Rank
Structure CB_VK055_3892
Pocket No pockets
ColabFold model
FPocket 0.598 · Pocket 4
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 158 / 4744 genomes with a hit
Normalized 0.033

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0009306 The controlled release of proteins from a cell.
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0015450 Primary active carrier-mediated transport of a protein across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated.

Sequence Features

Domain/signature hits from InterPro and related databases.

17 records
Show feature table
Start End DB Term Name
1 54 NCBIfam TIGR00810 preprotein translocase subunit SecG
1 54 InterPro IPR004692 Preprotein translocase SecG subunit
51 89 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
59 89 MobiDBLite mobidb-lite consensus disorder prediction
1 30 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
34 56 PRINTS PR01651 Protein-export SecG membrane protein signature
34 56 InterPro IPR004692 Preprotein translocase SecG subunit
18 34 PRINTS PR01651 Protein-export SecG membrane protein signature
18 34 InterPro IPR004692 Preprotein translocase SecG subunit
3 17 PRINTS PR01651 Protein-export SecG membrane protein signature
3 17 InterPro IPR004692 Preprotein translocase SecG subunit
1 52 Pfam PF03840 Preprotein translocase SecG subunit
1 52 InterPro IPR004692 Preprotein translocase SecG subunit
31 50 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 81 PANTHER PTHR34182 PROTEIN-EXPORT MEMBRANE PROTEIN SECG
1 81 InterPro IPR004692 Preprotein translocase SecG subunit
31 53 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
ColabFold VK055_3892
ColabFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
4 0.598
3 0.03
1 0.003
2 0.001