Protein profile

VK055_3915

GIY-YIG catalytic domain protein

Genome: KpATCC43816

Gene: AIK82464.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GW33

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Amino acids 96

Annotations 0

Features 12

PDB binders 0

Druggability 0.234

Overview

Basic information about this protein and its source genome.

Accession: VK055_3915
Assembly: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene: AIK82464.1
Status: annotated
Amino acids: 96
Structure source: AlphaFold + ColabFold

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Human identity (%): 0.0
Gut microbiome off-target: hit
Essential (DEG): Y
DEG identity (%): 74.444
DEG E-value: 2.4800000000000003e-43
Localization: Cytoplasmic
ColabFold pLDDT: 90.72

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.234

Structure A0A0H3GW33

Pocket Pocket 1

P2Rank 0.004

Structure A0A0H3GW33

Pocket Pocket 1

ColabFold model

FPocket 0.154 · Pocket 1

Core conservation Conserved core gene

Roary core

CoreCruncher core

Gut microbiome 121 / 4744 genomes with a hit

Normalized 0.026

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

12 records

Show feature table

Start	End	DB	Term	Name
5	72	CDD	cd10456	GIY-YIG_UPF0213
3	78	ProSiteProfiles	PS50164	GIY-YIG domain profile.
3	78	InterPro	IPR000305	GIY-YIG endonuclease
1	90	PANTHER	PTHR34477	UPF0213 PROTEIN YHBQ
4	75	Pfam	PF01541	GIY-YIG catalytic domain
4	75	InterPro	IPR000305	GIY-YIG endonuclease
2	94	Gene3D	G3DSA:3.40.1440.10	-
2	94	InterPro	IPR035901	GIY-YIG endonuclease superfamily
5	74	SUPERFAMILY	SSF82771	GIY-YIG endonuclease
5	74	InterPro	IPR035901	GIY-YIG endonuclease superfamily
2	93	Hamap	MF_01029	UPF0213 protein YhbQ [yhbQ].
2	93	InterPro	IPR022992	Uncharacterised protein family UPF0213, GIY-YIG endonuclease

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold AF_A0A0H3GW33	AlphaFold	—	—	full sequence	—	Viewing
ColabFold VK055_3915	ColabFold	—	—	full sequence	—	Loaded

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.234