Protein profile

VK055_3972

dihydroxyacetone kinase, L subunit

Genome: KpATCC43816

Gene: AIK82520.1 dhaL Structure source: AlphaFold + ColabFold UniProt A0A0H3GYP2
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Amino acids 210
Annotations 5
Features 14
PDB binders 0
Druggability 0.761

Overview

Basic information about this protein and its source genome.

Accession
VK055_3972
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK82520.1 dhaL
Status
annotated
Amino acids
210
Structure source
AlphaFold + ColabFold
GO
GO:0016772 Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). GO:0006071 The chemical reactions and pathways involving glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids. GO:0004371 Catalysis of the reaction: ATP + glycerone = ADP + glycerone phosphate + 2 H+. GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0019563 The chemical reactions and pathways resulting in the breakdown of glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
32.418
Human E-value
4.49e-12
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
83.333
DEG E-value
2.64e-127
Localization
Cytoplasmic
ColabFold pLDDT
97.86

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.761
Structure A0A0H3GYP2
Pocket Pocket 1
P2Rank 0.886
Structure A0A0H3GYP2
Pocket Pocket 1
ColabFold model
FPocket 0.784 · Pocket 1
P2Rank 0.841 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 69 / 4744 genomes with a hit
Normalized 0.015

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0016772 Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor).
  • GO:0006071 The chemical reactions and pathways involving glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids.
  • GO:0004371 Catalysis of the reaction: ATP + glycerone = ADP + glycerone phosphate + 2 H+.
  • GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
  • GO:0019563 The chemical reactions and pathways resulting in the breakdown of glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids.

Sequence Features

Domain/signature hits from InterPro and related databases.

14 records
Show feature table
Start End DB Term Name
1 210 Gene3D G3DSA:1.25.40.340 -
1 210 InterPro IPR036117 DhaL domain superfamily
6 206 ProSiteProfiles PS51480 DhaL domain profile.
6 206 InterPro IPR004007 DhaL domain
33 205 Pfam PF02734 DAK2 domain
33 205 InterPro IPR004007 DhaL domain
32 206 SMART SM01120 Dak2_2
32 206 InterPro IPR004007 DhaL domain
2 205 SUPERFAMILY SSF101473 DhaL-like
2 205 InterPro IPR036117 DhaL domain superfamily
9 205 NCBIfam TIGR02365 dihydroxyacetone kinase subunit DhaL
9 205 InterPro IPR012737 Dihydroxyacetone kinase, subunit L
20 208 PANTHER PTHR28629 TRIOKINASE/FMN CYCLASE
4 209 FunFam G3DSA:1.25.40.340:FF:000002 Dihydroxyacetone kinase, L subunit

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GYP2
AlphaFold — — full sequence — Viewing
ColabFold VK055_3972
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.761

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 14.64 0.729
2 1.63 0.027