Protein profile

VK055_3986

hdeA/HdeB family protein

Genome: KpATCC43816

Gene: AIK82534.1 Structure source: ColabFold
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Amino acids 83
Annotations 2
Features 6
PDB binders 0
Druggability 0.228

Overview

Basic information about this protein and its source genome.

Accession
VK055_3986
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK82534.1
Status
annotated
Amino acids
83
Structure source
ColabFold
GO
GO:0009268 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus. pH is a measure of the acidity or basicity of an aqueous solution. GO:0051082 Binding to an unfolded protein.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
45.714
DEG E-value
3.1e-19
Localization
Unknown
ColabFold pLDDT
91.82

Selected Druggability evidence

ColabFold / curated model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.228
Structure CB_VK055_3986
Pocket Pocket 2
P2Rank
Structure CB_VK055_3986
Pocket No pockets
ColabFold model
FPocket 0.228 · Pocket 2
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 31 / 4744 genomes with a hit
Normalized 0.007

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0009268 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus. pH is a measure of the acidity or basicity of an aqueous solution.
  • GO:0051082 Binding to an unfolded protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

6 records
Show feature table
Start End DB Term Name
1 82 Hamap MF_00947 Acid stress chaperone HdeB [hdeB].
1 82 InterPro IPR028623 HNS-dependent expression B
7 83 Gene3D G3DSA:1.10.890.10 -
7 83 InterPro IPR038303 HNS-dependent expression A/B superfamily
2 75 Pfam PF06411 HdeA/HdeB family
2 75 InterPro IPR010486 HNS-dependent expression A/B

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
ColabFold VK055_3986
ColabFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.228