Protein profile

VK055_3987

hypothetical protein

Genome: KpATCC43816

Gene: AIK82535.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GYN4
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Amino acids 191
Annotations 1
Features 26
PDB binders 0
Druggability 0.709

Overview

Basic information about this protein and its source genome.

Accession
VK055_3987
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK82535.1
Status
annotated
Amino acids
191
Structure source
AlphaFold + ColabFold
GO
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
85.04

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.709
Structure A0A0H3GYN4
Pocket Pocket 17
P2Rank 0.059
Structure A0A0H3GYN4
Pocket Pocket 1
ColabFold model
FPocket 0.769 · Pocket 4
P2Rank 0.086 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 5 / 4744 genomes with a hit
Normalized 0.001

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Sequence Features

Domain/signature hits from InterPro and related databases.

26 records
Show feature table
Start End DB Term Name
104 126 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
160 182 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
36 40 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
156 160 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 40 Phobius SIGNAL_PEPTIDE Signal peptide region
41 49 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
133 155 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
24 35 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
24 187 PANTHER PTHR34989 PROTEIN HDED
26 97 Pfam PF03729 Short repeat of unknown function (DUF308)
26 97 InterPro IPR005325 Protein of unknown function DUF308, membrane
86 152 Pfam PF03729 Short repeat of unknown function (DUF308)
86 152 InterPro IPR005325 Protein of unknown function DUF308, membrane
49 71 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
99 103 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
136 155 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
183 191 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
78 100 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 23 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
80 98 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
125 135 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
50 71 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
23 45 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
72 79 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
161 182 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
104 124 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GYN4
AlphaFold — — full sequence — Viewing
ColabFold VK055_3987
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
17 0.709

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 2.15 0.05
2 1.74 0.031
3 1.2 0.01