Protein profile

VK055_3997

ribosomal protein S21

Genome: KpATCC43816

Gene: rpsU AIK82544.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GXT4
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Amino acids 71
Annotations 4
Features 23
PDB binders 0
Druggability 0.801

Overview

Basic information about this protein and its source genome.

Accession
VK055_3997
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
rpsU AIK82544.1
Status
annotated
Amino acids
71
Structure source
AlphaFold + ColabFold
GO
GO:0003735 The action of a molecule that contributes to the structural integrity of the ribosome. GO:0006412 The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome. GO:0005840 An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. GO:1990904 A macromolecular complex that contains both RNA and protein molecules.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
100.0
DEG E-value
2.23e-45
Localization
Cytoplasmic
ColabFold pLDDT
83.84

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.801
Structure A0A0H3GXT4
Pocket Pocket 5
P2Rank
Structure A0A0H3GXT4
Pocket No pockets
ColabFold model
FPocket 0.471 · Pocket 5
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 1066 / 4744 genomes with a hit
Normalized 0.225

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0003735 The action of a molecule that contributes to the structural integrity of the ribosome.
  • GO:0006412 The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome.
  • GO:0005840 An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins.
  • GO:1990904 A macromolecular complex that contains both RNA and protein molecules.

Sequence Features

Domain/signature hits from InterPro and related databases.

23 records
Show feature table
Start End DB Term Name
1 57 Hamap MF_00358 30S ribosomal protein S21 [rpsU].
1 57 InterPro IPR001911 Ribosomal protein S21
13 25 ProSitePatterns PS01181 Ribosomal protein S21 signature.
13 25 InterPro IPR018278 Ribosomal protein S21, conserved site
16 54 Gene3D G3DSA:1.20.5.1150 Ribosomal protein S8
16 54 InterPro IPR038380 Ribosomal protein S21 superfamily
49 63 MobiDBLite mobidb-lite consensus disorder prediction
4 59 PANTHER PTHR21109 MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S21
4 59 InterPro IPR001911 Ribosomal protein S21
4 56 Pfam PF01165 Ribosomal protein S21
4 56 InterPro IPR001911 Ribosomal protein S21
2 59 NCBIfam TIGR00030 30S ribosomal protein S21
2 59 InterPro IPR001911 Ribosomal protein S21
47 71 MobiDBLite mobidb-lite consensus disorder prediction
16 54 FunFam G3DSA:1.20.5.1150:FF:000001 30S ribosomal protein S21
13 22 PRINTS PR00976 Ribosomal protein S21 family signature
13 22 InterPro IPR001911 Ribosomal protein S21
25 35 PRINTS PR00976 Ribosomal protein S21 family signature
25 35 InterPro IPR001911 Ribosomal protein S21
37 47 PRINTS PR00976 Ribosomal protein S21 family signature
37 47 InterPro IPR001911 Ribosomal protein S21
5 13 PRINTS PR00976 Ribosomal protein S21 family signature
5 13 InterPro IPR001911 Ribosomal protein S21

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GXT4
AlphaFold — — full sequence — Viewing
ColabFold VK055_3997
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
5 0.801