Protein profile

VK055_4016

glnD PII-uridylyltransferase family protein

Genome: KpATCC43816

Gene: AIK82563.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3H378
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Amino acids 945
Annotations 2
Features 34
PDB binders 0
Druggability 0.458

Overview

Basic information about this protein and its source genome.

Accession
VK055_4016
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK82563.1
Status
annotated
Amino acids
945
Structure source
AlphaFold + ColabFold
GO
GO:0016779 Catalysis of the transfer of a nucleotidyl group from one compound (donor) to another (acceptor). GO:0008882 Catalysis of the reaction: ATP + [L-glutamate:ammonia ligase (ADP-forming)] = diphosphate + adenylyl-[L-glutamate:ammonia ligase (ADP-forming)].

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
29.888
Localization
Cytoplasmic
ColabFold pLDDT
92.25

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.458
Structure A0A0H3H378
Pocket Pocket 7
P2Rank 0.67
Structure A0A0H3H378
Pocket Pocket 1
ColabFold model
FPocket 0.125 · Pocket 69
P2Rank 0.624 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 142 / 4744 genomes with a hit
Normalized 0.03

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0016779 Catalysis of the transfer of a nucleotidyl group from one compound (donor) to another (acceptor).
  • GO:0008882 Catalysis of the reaction: ATP + [L-glutamate:ammonia ligase (ADP-forming)] = diphosphate + adenylyl-[L-glutamate:ammonia ligase (ADP-forming)].

Sequence Features

Domain/signature hits from InterPro and related databases.

34 records
Show feature table
Start End DB Term Name
619 810 CDD cd05401 NT_GlnE_GlnD_like
285 440 Gene3D G3DSA:1.20.120.330 Nucleotidyltransferases domain 2
93 282 CDD cd05401 NT_GlnE_GlnD_like
1 110 FunFam G3DSA:1.10.4050.10:FF:000001 Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme
812 945 FunFam G3DSA:1.20.120.330:FF:000008 Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme
27 945 Hamap MF_00802 Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme [glnE].
27 945 InterPro IPR023057 Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme
11 944 PANTHER PTHR30621 GLUTAMINE SYNTHETASE ADENYLYLTRANSFERASE
11 944 InterPro IPR023057 Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme
28 286 SUPERFAMILY SSF81301 Nucleotidyltransferase
28 286 InterPro IPR043519 Nucleotidyltransferase superfamily
287 436 SUPERFAMILY SSF81593 Nucleotidyltransferase substrate binding subunit/domain
562 811 Gene3D G3DSA:3.30.460.10 Beta Polymerase, domain 2
562 811 InterPro IPR043519 Nucleotidyltransferase superfamily
31 275 Pfam PF03710 Glutamate-ammonia ligase adenylyltransferase
31 275 InterPro IPR005190 Glutamate-ammonia ligase adenylyltransferase, repeated domain
553 805 Pfam PF03710 Glutamate-ammonia ligase adenylyltransferase
553 805 InterPro IPR005190 Glutamate-ammonia ligase adenylyltransferase, repeated domain
1 110 Gene3D G3DSA:1.10.4050.10 Glutamine synthase adenylyltransferase GlnE
111 284 Gene3D G3DSA:3.30.460.10 Beta Polymerase, domain 2
111 284 InterPro IPR043519 Nucleotidyltransferase superfamily
818 943 SUPERFAMILY SSF81593 Nucleotidyltransferase substrate binding subunit/domain
449 561 Gene3D G3DSA:1.20.120.1510 -
525 815 SUPERFAMILY SSF81301 Nucleotidyltransferase
525 815 InterPro IPR043519 Nucleotidyltransferase superfamily
111 284 FunFam G3DSA:3.30.460.10:FF:000014 Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme
449 561 FunFam G3DSA:1.20.120.1510:FF:000001 Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme
812 945 Gene3D G3DSA:1.20.120.330 Nucleotidyltransferases domain 2
562 811 FunFam G3DSA:3.30.460.10:FF:000009 Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme
285 439 FunFam G3DSA:1.20.120.330:FF:000005 Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme
297 436 Pfam PF08335 GlnD PII-uridylyltransferase
297 436 InterPro IPR013546 PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
825 917 Pfam PF08335 GlnD PII-uridylyltransferase
825 917 InterPro IPR013546 PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3H378
AlphaFold — — full sequence — Viewing
ColabFold VK055_4016
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
61 0.026
84 0.014
24 0.012
83 0.0

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 15.35 0.67
2 12.61 0.572
3 6.15 0.254
4 5.79 0.233
5 5.08 0.191