Protein profile

VK055_4041

acetyltransferase family protein

Genome: KpATCC43816

Gene: AIK82588.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GVP1
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Amino acids 175
Annotations 1
Features 8
PDB binders 0
Druggability 0.885

Overview

Basic information about this protein and its source genome.

Accession
VK055_4041
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK82588.1
Status
annotated
Amino acids
175
Structure source
AlphaFold + ColabFold
GO
GO:0016747 Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
96.53

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.885
Structure A0A0H3GVP1
Pocket Pocket 1
P2Rank 0.919
Structure A0A0H3GVP1
Pocket Pocket 1
ColabFold model
FPocket 0.977 · Pocket 1
P2Rank 0.932 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 6 / 4744 genomes with a hit
Normalized 0.001

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0016747 Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).

Sequence Features

Domain/signature hits from InterPro and related databases.

8 records
Show feature table
Start End DB Term Name
68 134 CDD cd04301 NAT_SF
6 159 Gene3D G3DSA:3.40.630.30 -
12 154 SUPERFAMILY SSF55729 Acyl-CoA N-acyltransferases (Nat)
12 154 InterPro IPR016181 Acyl-CoA N-acyltransferase
12 175 ProSiteProfiles PS51186 Gcn5-related N-acetyltransferase (GNAT) domain profile.
12 175 InterPro IPR000182 GNAT domain
61 147 Pfam PF00583 Acetyltransferase (GNAT) family
61 147 InterPro IPR000182 GNAT domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GVP1
AlphaFold — — full sequence — Viewing
ColabFold VK055_4041
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.885

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 24.22 0.897
2 1.58 0.025