Protein profile

VK055_4044

bacterial regulatory helix-turn-helix, AraC family protein

Genome: KpATCC43816

Gene: AIK82591.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GTD6
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Amino acids 299
Annotations 3
Features 18
PDB binders 0
Druggability 0.172

Overview

Basic information about this protein and its source genome.

Accession
VK055_4044
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK82591.1
Status
annotated
Amino acids
299
Structure source
AlphaFold + ColabFold
GO
GO:0043565 Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
31.429
Localization
Cytoplasmic
ColabFold pLDDT
93.63

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.172
Structure A0A0H3GTD6
Pocket Pocket 6
P2Rank 0.195
Structure A0A0H3GTD6
Pocket Pocket 1
ColabFold model
FPocket 0.495 · Pocket 1
P2Rank 0.076 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 98 / 4744 genomes with a hit
Normalized 0.021

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0043565 Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
  • GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

Sequence Features

Domain/signature hits from InterPro and related databases.

18 records
Show feature table
Start End DB Term Name
213 288 Pfam PF12833 Helix-turn-helix domain
213 288 InterPro IPR018060 DNA binding HTH domain, AraC-type
186 299 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
5 297 PANTHER PTHR43436 ARAC-FAMILY TRANSCRIPTIONAL REGULATOR
167 185 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
241 293 Gene3D G3DSA:1.10.10.60 -
191 241 SUPERFAMILY SSF46689 Homeodomain-like
191 241 InterPro IPR009057 Homeobox-like domain superfamily
28 178 Pfam PF06719 AraC-type transcriptional regulator N-terminus
28 178 InterPro IPR009594 Transcription regulator HTH, AraC, N-terminal
243 292 SUPERFAMILY SSF46689 Homeodomain-like
243 292 InterPro IPR009057 Homeobox-like domain superfamily
183 240 Gene3D G3DSA:1.10.10.60 -
207 290 SMART SM00342 aracneu4
207 290 InterPro IPR018060 DNA binding HTH domain, AraC-type
1 166 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
194 292 ProSiteProfiles PS01124 Bacterial regulatory proteins, araC family DNA-binding domain profile.
194 292 InterPro IPR018060 DNA binding HTH domain, AraC-type

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GTD6
AlphaFold — — full sequence — Viewing
ColabFold VK055_4044
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 3.73 0.143
2 0.98 0.005