Protein profile

VK055_4086

branched-chain amino acid transport system / permease component family protein

Genome: KpATCC43816

Gene: AIK82632.1 Structure source: AlphaFold + ColabFold UniProt A0A0C7KIH5
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Amino acids 415
Annotations 4
Features 41
PDB binders 0
Druggability 0.987

Overview

Basic information about this protein and its source genome.

Accession
VK055_4086
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK82632.1
Status
annotated
Amino acids
415
Structure source
AlphaFold + ColabFold
GO
GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
39.706
Localization
CytoplasmicMembrane
ColabFold pLDDT
89.19

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.987
Structure A0A0C7KIH5
Pocket Pocket 21
P2Rank 0.92
Structure A0A0C7KIH5
Pocket Pocket 1
ColabFold model
FPocket 0.997 · Pocket 23
P2Rank 0.932 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 5 / 4744 genomes with a hit
Normalized 0.001

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Sequence Features

Domain/signature hits from InterPro and related databases.

41 records
Show feature table
Start End DB Term Name
97 115 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
275 301 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
170 188 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
212 231 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
189 211 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
116 120 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
255 274 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
231 250 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
121 143 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
256 274 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
386 405 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
406 415 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
363 380 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
97 116 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
35 409 PANTHER PTHR32196 ABC TRANSPORTER PERMEASE PROTEIN YPHD-RELATED-RELATED
144 149 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
150 169 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
232 250 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 39 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
381 385 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
361 383 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
338 356 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
40 63 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
251 255 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
189 211 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
91 96 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
64 68 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
121 143 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
327 337 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
357 362 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
302 326 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
388 405 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
77 402 CDD cd06579 TM_PBP1_transp_AraH_like
70 92 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
302 324 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
69 398 Pfam PF02653 Branched-chain amino acid transport system / permease component
69 398 InterPro IPR001851 ABC transporter, permease
69 90 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
334 356 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
43 65 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
150 169 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0C7KIH5
AlphaFold — — full sequence — Viewing
ColabFold VK055_4086
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
21 0.987
10 0.222

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 31.5 0.939
2 5.92 0.29
3 3.25 0.113
4 3.2 0.11
5 2.22 0.054