Protein profile

VK055_4153

helix-turn-helix domain, rpiR family protein

Genome: KpATCC43816

Gene: AIK82699.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GSX1
Export view
Amino acids 242
Annotations 5
Features 20
PDB binders 0
Druggability 0.233

Overview

Basic information about this protein and its source genome.

Accession
VK055_4153
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK82699.1
Status
annotated
Amino acids
242
Structure source
AlphaFold + ColabFold
GO
GO:0097367 Binding to a carbohydrate derivative. GO:1901135 The chemical reactions and pathways involving carbohydrate derivative. GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
91.78

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.233
Structure A0A0H3GSX1
Pocket Pocket 6
P2Rank 0.064
Structure A0A0H3GSX1
Pocket Pocket 1
ColabFold model
FPocket 0.477 · Pocket 8
P2Rank 0.062 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 86 / 4744 genomes with a hit
Normalized 0.018

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0097367 Binding to a carbohydrate derivative.
  • GO:1901135 The chemical reactions and pathways involving carbohydrate derivative.
  • GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Sequence Features

Domain/signature hits from InterPro and related databases.

20 records
Show feature table
Start End DB Term Name
110 224 Pfam PF01380 SIS domain
110 224 InterPro IPR001347 SIS domain
9 71 Pfam PF01418 Helix-turn-helix domain, rpiR family
9 71 InterPro IPR000281 Helix-turn-helix protein RpiR
1 73 ProSiteProfiles PS51071 RpiR-type HTH domain profile.
1 73 InterPro IPR000281 Helix-turn-helix protein RpiR
4 77 Gene3D G3DSA:1.10.10.10 -
4 77 InterPro IPR036388 Winged helix-like DNA-binding domain superfamily
86 230 SUPERFAMILY SSF53697 SIS domain
86 230 InterPro IPR046348 SIS domain superfamily
78 242 Gene3D G3DSA:3.40.50.10490 -
7 73 SUPERFAMILY SSF46689 Homeodomain-like
7 73 InterPro IPR009057 Homeobox-like domain superfamily
33 51 ProSitePatterns PS00356 LacI-type HTH domain signature.
7 239 PANTHER PTHR30514 GLUCOKINASE
7 239 InterPro IPR047640 HTH-type transcriptional regulator RpiR-like
99 233 CDD cd05013 SIS_RpiR
99 233 InterPro IPR035472 RpiR-like, SIS domain
104 240 ProSiteProfiles PS51464 SIS domain profile.
104 240 InterPro IPR001347 SIS domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GSX1
AlphaFold — — full sequence — Viewing
ColabFold VK055_4153
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
6 0.233