Protein profile

VK055_4190

ureD urease accessory family protein

Genome: KpATCC43816

Gene: AIK82735.1 Structure source: AlphaFold + ColabFold UniProt A0A2L1BUB7
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Amino acids 316
Annotations 3
Features 6
PDB binders 0
Druggability 0.714

Overview

Basic information about this protein and its source genome.

Accession
VK055_4190
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK82735.1
Status
annotated
Amino acids
316
Structure source
AlphaFold + ColabFold
GO
GO:0016151 Binding to a nickel (Ni) cation. GO:0006807 OBSOLETE. The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen. GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
94.14

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.714
Structure A0A2L1BUB7
Pocket Pocket 4
P2Rank 0.852
Structure A0A2L1BUB7
Pocket Pocket 1
ColabFold model
FPocket 0.842 · Pocket 4
P2Rank 0.876 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 21 / 4744 genomes with a hit
Normalized 0.004

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0016151 Binding to a nickel (Ni) cation.
  • GO:0006807 OBSOLETE. The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen.
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

Sequence Features

Domain/signature hits from InterPro and related databases.

6 records
Show feature table
Start End DB Term Name
40 300 Hamap MF_01384 Urease accessory protein UreD [ureD].
40 300 InterPro IPR002669 Urease accessory protein UreD
86 289 Pfam PF01774 UreD urease accessory protein
86 289 InterPro IPR002669 Urease accessory protein UreD
30 301 PANTHER PTHR33643 UREASE ACCESSORY PROTEIN D
30 301 InterPro IPR002669 Urease accessory protein UreD

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A2L1BUB7
AlphaFold — — full sequence — Viewing
ColabFold VK055_4190
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
4 0.714
9 0.23

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 17.27 0.8
2 13.25 0.679
3 3.93 0.155
4 1.83 0.035
5 1.56 0.024