Protein profile

VK055_4193

ureE urease accessory, N-terminal domain protein

Genome: KpATCC43816

Gene: AIK82738.1 Structure source: AlphaFold + ColabFold UniProt A0A483PG95
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Amino acids 212
Annotations 6
Features 15
PDB binders 0
Druggability 0.241

Overview

Basic information about this protein and its source genome.

Accession
VK055_4193
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK82738.1
Status
annotated
Amino acids
212
Structure source
AlphaFold + ColabFold
GO
GO:0019627 The chemical reactions and pathways involving urea, the water soluble compound O=C-(NH2)2. GO:0006457 The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. GO:0065003 The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex. GO:0016151 Binding to a nickel (Ni) cation. GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0051082 Binding to an unfolded protein.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
83.54

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.241
Structure A0A483PG95
Pocket Pocket 11
P2Rank 0.016
Structure A0A483PG95
Pocket Pocket 1
ColabFold model
FPocket 0.208 · Pocket 10
P2Rank 0.034 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 17 / 4744 genomes with a hit
Normalized 0.004

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

6 GO

Gene Ontology (GO)

6
  • GO:0019627 The chemical reactions and pathways involving urea, the water soluble compound O=C-(NH2)2.
  • GO:0006457 The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.
  • GO:0065003 The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex.
  • GO:0016151 Binding to a nickel (Ni) cation.
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
  • GO:0051082 Binding to an unfolded protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

15 records
Show feature table
Start End DB Term Name
85 210 Pfam PF05194 UreE urease accessory protein, C-terminal domain
85 210 InterPro IPR007864 Urease accessory protein UreE, C-terminal domain
3 76 SUPERFAMILY SSF69287 Urease metallochaperone UreE, N-terminal domain
3 76 InterPro IPR036118 UreE urease accessory, N-terminal domain superfamily
7 75 SMART SM00988 UreE_n_2_a
7 75 InterPro IPR004029 UreE urease accessory, N-terminal
2 177 Hamap MF_00822 Urease accessory protein UreE [ureE].
2 177 InterPro IPR012406 Urease accessory protein UreE
187 212 MobiDBLite mobidb-lite consensus disorder prediction
2 212 PIRSF PIRSF036402 Ureas_acces_UreE
2 212 InterPro IPR012406 Urease accessory protein UreE
1 79 Gene3D G3DSA:2.60.260.20 -
15 72 Pfam PF02814 UreE urease accessory protein, N-terminal domain
15 72 InterPro IPR004029 UreE urease accessory, N-terminal
197 212 MobiDBLite mobidb-lite consensus disorder prediction

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A483PG95
AlphaFold — — full sequence — Viewing
ColabFold VK055_4193
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
11 0.241