Protein profile

VK055_4198

acid stress chaperone

Genome: KpATCC43816

Gene: AIK82743.1 hdeB Structure source: AlphaFold + ColabFold UniProt A0A2L1BU11
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Amino acids 113
Annotations 4
Features 13
PDB binders 0
Druggability 0.481

Overview

Basic information about this protein and its source genome.

Accession
VK055_4198
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK82743.1 hdeB
Status
annotated
Amino acids
113
Structure source
AlphaFold + ColabFold
GO
GO:0009268 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus. pH is a measure of the acidity or basicity of an aqueous solution. GO:0051082 Binding to an unfolded protein. GO:0042597 The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria). GO:1990451 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in the homeostasis of organismal or cellular pH (with pH < 7). pH is a measure of the acidity or basicity of an aqueous solution.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
47.872
DEG E-value
7.13e-29
Localization
Unknown
ColabFold pLDDT
76.53

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.481
Structure A0A2L1BU11
Pocket Pocket 3
P2Rank 0.003
Structure A0A2L1BU11
Pocket Pocket 1
ColabFold model
FPocket 0.522 · Pocket 4
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 8 / 4744 genomes with a hit
Normalized 0.002

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0009268 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus. pH is a measure of the acidity or basicity of an aqueous solution.
  • GO:0051082 Binding to an unfolded protein.
  • GO:0042597 The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).
  • GO:1990451 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in the homeostasis of organismal or cellular pH (with pH < 7). pH is a measure of the acidity or basicity of an aqueous solution.

Sequence Features

Domain/signature hits from InterPro and related databases.

13 records
Show feature table
Start End DB Term Name
1 35 Phobius SIGNAL_PEPTIDE Signal peptide region
29 35 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
1 16 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
17 28 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
1 35 SignalP_GRAM_NEGATIVE SignalP-noTM SignalP-noTM
12 113 Hamap MF_00947 Acid stress chaperone HdeB [hdeB].
12 113 InterPro IPR028623 HNS-dependent expression B
38 113 Gene3D G3DSA:1.10.890.10 -
38 113 InterPro IPR038303 HNS-dependent expression A/B superfamily
36 113 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 35 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
24 107 Pfam PF06411 HdeA/HdeB family
24 107 InterPro IPR010486 HNS-dependent expression A/B

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A2L1BU11
AlphaFold — — full sequence — Viewing
ColabFold VK055_4198
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
3 0.481
1 0.2
4 0.001
2 0.0

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 0.88 0.003