Protein profile

VK055_4208

carboxymuconolactone decarboxylase family protein

Genome: KpATCC43816

Gene: AIK82753.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GV34
Export view
Amino acids 267
Annotations 1
Features 14
PDB binders 0
Druggability 0.578

Overview

Basic information about this protein and its source genome.

Accession
VK055_4208
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK82753.1
Status
annotated
Amino acids
267
Structure source
AlphaFold + ColabFold
GO
GO:0051920 Catalysis of the reaction: [protein]-dithol + ROOH = [protein]-disulfide + H2O + ROH.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
91.26

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.578
Structure A0A0H3GV34
Pocket Pocket 1
P2Rank 0.172
Structure A0A0H3GV34
Pocket Pocket 1
ColabFold model
FPocket 0.845 · Pocket 1
P2Rank 0.232 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 19 / 4744 genomes with a hit
Normalized 0.004

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0051920 Catalysis of the reaction: [protein]-dithol + ROOH = [protein]-disulfide + H2O + ROH.

Sequence Features

Domain/signature hits from InterPro and related databases.

14 records
Show feature table
Start End DB Term Name
1 20 Phobius SIGNAL_PEPTIDE Signal peptide region
4 15 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
1 20 SignalP_GRAM_NEGATIVE SignalP-noTM SignalP-noTM
16 20 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
41 135 PANTHER PTHR33570 4-CARBOXYMUCONOLACTONE DECARBOXYLASE FAMILY PROTEIN
21 267 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
29 264 SUPERFAMILY SSF69118 AhpD-like
29 264 InterPro IPR029032 AhpD-like
1 3 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
53 130 Pfam PF02627 Carboxymuconolactone decarboxylase family
53 130 InterPro IPR003779 Carboxymuconolactone decarboxylase-like
175 254 Pfam PF02627 Carboxymuconolactone decarboxylase family
175 254 InterPro IPR003779 Carboxymuconolactone decarboxylase-like
29 264 Gene3D G3DSA:1.20.1290.10 -

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GV34
AlphaFold — — full sequence — Viewing
ColabFold VK055_4208
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.578
2 0.051
3 0.0
8 0.0

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 4.74 0.172
2 2.66 0.063
3 2.63 0.062
4 2.37 0.051