Protein profile

VK055_4291

prepilin-type N-terminal cleavage/methylation domain protein

Genome: KpATCC43816

Gene: AIK82836.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GSM5
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Amino acids 185
Annotations 2
Features 12
PDB binders 0
Druggability 0.144

Overview

Basic information about this protein and its source genome.

Accession
VK055_4291
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK82836.1
Status
annotated
Amino acids
185
Structure source
AlphaFold + ColabFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015628 The process in which proteins are secreted across the outer membrane of Gram-negative bacteria by the type II secretion system. Proteins using this pathway are first translocated across the cytoplasmic membrane via the Sec or Tat pathways.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
94.34

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.144
Structure A0A0H3GSM5
Pocket Pocket 1
P2Rank
Structure A0A0H3GSM5
Pocket No pockets
ColabFold model
FPocket 0.598 · Pocket 1
P2Rank 0.014 · Pocket 1
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 58 / 4744 genomes with a hit
Normalized 0.012

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0015628 The process in which proteins are secreted across the outer membrane of Gram-negative bacteria by the type II secretion system. Proteins using this pathway are first translocated across the cytoplasmic membrane via the Sec or Tat pathways.

Sequence Features

Domain/signature hits from InterPro and related databases.

12 records
Show feature table
Start End DB Term Name
1 185 PIRSF PIRSF004525 Pilin_peptidase-dep_B
1 185 InterPro IPR016419 Prepilin peptidase-dependent protein B, predicted
1 5 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
3 150 PANTHER PTHR39583 TYPE II SECRETION SYSTEM PROTEIN J-RELATED
30 185 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
6 29 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 26 ProSiteProfiles PS51257 Prokaryotic membrane lipoprotein lipid attachment site profile.
3 25 NCBIfam TIGR02532 prepilin-type N-terminal cleavage/methylation domain
3 25 InterPro IPR012902 Prokaryotic N-terminal methylation site
2 25 Pfam PF07963 Prokaryotic N-terminal methylation motif
2 25 InterPro IPR012902 Prokaryotic N-terminal methylation site
7 29 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GSM5
AlphaFold — — full sequence — Viewing
ColabFold VK055_4291
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer